Department of Pathology.
Army Medical College NUMS, Islamabad.
J Ayub Med Coll Abbottabad. 2023 Jul-Sep;35(3):400-404. doi: 10.55519/JAMC-03-11495.
Fibro-adenoma is the most common benign condition of the female breast comprising about 68% of all breast lumps. Fibroadenoma is an independent risk factor for the development of breast cancer. Complex fibroadenoma has a 2-3-fold increased risk ratio and simple fibroadenoma has 1.49 times increased risk ratio of developing cancer than the normal population over a period of 20 years. This study aimed to qualitatively check the frequency of oestrogen receptor-positive and progesterone receptor-positive cases of fibroadenoma in our region.
This cross-sectional study was conducted in the pathology department of Ayub Medical College, Abbottabad from June 2020 to December 2021. Biopsy confirmed cases of fibroadenoma were examined using immune-histochemical stains to score qualitatively the expression pattern of ER and PR. Data was analyzed and assessed using SPSS version 25. A p-value of ≤0.05 was considered statistically significant.
The mean age of patients who presented with fibro-adenoma was 24.5±9.29 years with a median age of 21.5 years. In most cases, oestrogen receptor expression was mild 23 (54.76%) whereas progesterone receptor expression was severe 19 (45.23%). On chi-square test, the pattern of progesterone receptor expression for the category of hormone intake showed significant differences. Whereas, the pattern of oestrogen receptor expression for the categories of marital status, history of hormone intake, history of menstrual cycle and type of fibroadenoma showed no statistically significant difference.
Further study into the pathogenesis of fibroadenoma is required to understand the role of ER and PR and explore the therapeutic potential of such drugs that affects these receptors. Cabling.
纤维腺瘤是女性乳房最常见的良性病变，约占所有乳房肿块的 68%。纤维腺瘤是乳腺癌发生的独立危险因素。复杂纤维腺瘤的风险比是正常人群的 2-3 倍，而单纯纤维腺瘤在 20 年内发生癌症的风险比是正常人群的 1.49 倍。本研究旨在定性检查我们地区纤维腺瘤中雌激素受体阳性和孕激素受体阳性的频率。
这是一项在 2020 年 6 月至 2021 年 12 月期间在阿伯塔巴德阿尤布医学院病理学系进行的横断面研究。使用免疫组织化学染色检查活检证实的纤维腺瘤病例，以定性评分 ER 和 PR 的表达模式。使用 SPSS 版本 25 对数据进行分析和评估。p 值≤0.05 被认为具有统计学意义。
表现为纤维腺瘤的患者的平均年龄为 24.5±9.29 岁，中位年龄为 21.5 岁。在大多数情况下，雌激素受体表达为轻度 23 例（54.76%），而孕激素受体表达为重度 19 例（45.23%）。在卡方检验中，激素摄入类别中孕激素受体表达模式显示出显著差异。而在婚姻状况、激素摄入史、月经周期史和纤维腺瘤类型的类别中，雌激素受体表达模式没有统计学上的显著差异。
需要进一步研究纤维腺瘤的发病机制，以了解 ER 和 PR 的作用，并探讨影响这些受体的药物治疗潜力。
