Alatise O I, Babalola O O, Omoniyi-Esan G O, Lawal O O, Adesunkanmi A R, Agbakwuru E A
Department of Surgery, Faculty of Clinical Sciences Obafemi Awolowo University, Ile-Ife, Nigeria.
Niger Postgrad Med J. 2013 Jun;20(2):91-7.
The aim of this prospective case controlled study was to evaluate the tissue levels of selenium in patients with cases of fibroadenoma, cancer of the breast and in the controls in order to relate them to the occurrence of breast diseases.
Consecutive consenting patients who had histologically confirmed breast cancer and fibroadenoma attending the General surgical outpatients departments of Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, were recruited for the study. One gram of core disease breast tissues was taken for Selenium level estimation.
There were 127 female subjects;. 95 (74.8%) cases of fibroadenoma and 32 (25.2%) of breast cancer. While breast cancer was common on the left, fibroadenoma was more common on the right breast (? = 8.994; p=0.011). The median tissue level of selenium in patients with fibroadenoma was 0.0272 mg/g with a range of 0.0124 to 0.0576 mg/g and that of the cancer patients was 0.0178 mg/g with a range 0.0072 to 0.0436 mg/g. These were statistically significantly different ( p=0.001). Factors affecting tissue selenium level include age (p<0.001), overall stage of breast cancer (p<0.001), maximum length of breast mass (p=0.023), previous delivery (p=0.004), age at last confinement (p=0.007), parity (p<0.001), oestrogen receptor (ER) status (p<0.001) and progesterone receptor (PR) status (p=0.021).
Tissue selenium was lower in breast cancer than in fibroadenoma; Tissue selenium inhibits carcinogenesis; low tissue level of selenium therefore may be a factor in the development of breast cancer.
本前瞻性病例对照研究的目的是评估纤维腺瘤患者、乳腺癌患者及对照组的组织硒水平，以便将其与乳腺疾病的发生联系起来。
连续入选了在伊费奥巴费米·阿沃洛沃大学教学医院综合大楼普通外科门诊就诊、经组织学确诊为乳腺癌和纤维腺瘤的同意参与研究的患者。采集1克病灶核心乳腺组织用于硒水平测定。
共有127名女性受试者；其中95例（74.8%）为纤维腺瘤，32例（25.2%）为乳腺癌。乳腺癌在左侧更为常见，而纤维腺瘤在右侧乳房更为常见（χ² = 8.994；p = 0.011）。纤维腺瘤患者的组织硒水平中位数为0.0272毫克/克，范围为0.0124至0.0576毫克/克，癌症患者的组织硒水平中位数为0.0178毫克/克，范围为0.0072至0.0436毫克/克。这些在统计学上有显著差异（p = 0.001）。影响组织硒水平的因素包括年龄（p < 0.001）、乳腺癌的总体分期（p < 0.001）、乳腺肿块的最大长度（p = 0.023）、既往分娩情况（p = 0.004）、末次分娩年龄（p = 0.007）、产次（p < 0.001）、雌激素受体（ER）状态（p < 0.001）和孕激素受体（PR）状态（p = 0.021）。
乳腺癌患者的组织硒水平低于纤维腺瘤患者；组织硒抑制致癌作用；因此，组织硒水平低可能是乳腺癌发生的一个因素。
