Department of Pharmacology, Army Medical College, Rawalpindi, Pakistan.
Armed Forces Institute of Dentistry, Rawalpindi, Pakistan.
J Ayub Med Coll Abbottabad. 2023 Jul-Sep;35(3):442-446. doi: 10.55519/JAMC-03-11901.
Abstraction of wisdom teeth or impacted third molar under local anaesthesia is one of the most frequent interventions by an oral and maxillofacial surgeon. The abstraction of the third molar is usually followed by the release of liberation and consequent trismus, pain, and swelling due to the area of the third molar being highly vascularized and rich in loose connective tissue. Objective of the study was to evaluate the anti-inflammatory effect of ascorbic acid following surgical extraction of the third molar.
The current study was carried out Armed Forces Institute of Dentistry, Rawalpindi, from October to December 2022. This was a cross-sectional observational study. Fifty participants who required surgical extraction of the impacted third molar were included in the study via non-probability purposive sampling and were segregated equally into two groups, i.e., Group A and Group B, comprising twenty-five participants in each group. Group A received amoxicillin with clavulanic acid (625 mg) thrice a day and metronidazole (400 mg) twice daily. In comparison, Group B received amoxicillin with clavulanic acid (625 mg) thrice daily, ascorbic acid (500 mg) twice daily, and metronidazole (400 mg) twice daily. Both groups received naproxen sodium as per requirement (550 mg). Pain, facial swelling, and C reactive protein concentration were evaluated until the 7th postoperative day.
There was a reduction in pain and facial swelling in both groups, but in the ascorbic acid group, there was more reduction in pain and facial swelling compared to the control group. However, the difference between the two groups in reducing pain and facial swelling was statistically significant (p<0.01). There was a reduction in CRP in both groups, but in the ascorbic acid group, there was more reduction in CRP 2.35 (1.60-5.30) compared to the control group 2.6 (0.86-5.03). However, the difference between the two groups in reducing C reactive protein concentration was statistically insignificant (p>0.05).
Our study concluded that ascorbic acid significantly reduced inflammation and C reactive protein, so ascorbic acid should be used as an adjuvant supplement with other conventional drugs.
在局部麻醉下拔除智齿或埋伏第三磨牙是口腔颌面外科最常见的干预措施之一。由于第三磨牙区域高度血管化且富含疏松结缔组织，因此拔除第三磨牙后通常会出现释放、继而出现张口受限、疼痛和肿胀。本研究旨在评估手术后使用抗坏血酸对第三磨牙的抗炎作用。
本研究于 2022 年 10 月至 12 月在拉瓦尔品第的武装部队牙科研究所进行。这是一项横断面观察性研究。通过非概率目的抽样，将需要手术拔除埋伏第三磨牙的 50 名参与者纳入研究，并将他们平均分为两组，即 A 组和 B 组，每组 25 名参与者。A 组每天服用 3 次阿莫西林克拉维酸（625 毫克）和 2 次甲硝唑（400 毫克）。相比之下，B 组每天服用 3 次阿莫西林克拉维酸（625 毫克）、2 次抗坏血酸（500 毫克）和 2 次甲硝唑（400 毫克）。两组均根据需要服用萘普生钠（550 毫克）。直到术后第 7 天，评估疼痛、面部肿胀和 C 反应蛋白浓度。
两组的疼痛和面部肿胀均有所减轻，但抗坏血酸组的疼痛和面部肿胀减轻程度大于对照组。然而，两组在减轻疼痛和面部肿胀方面的差异具有统计学意义（p<0.01）。两组的 CRP 均有所降低，但抗坏血酸组的 CRP 降低更明显，为 2.35（1.60-5.30），而对照组为 2.6（0.86-5.03）。然而，两组在降低 C 反应蛋白浓度方面的差异无统计学意义（p>0.05）。
我们的研究表明，抗坏血酸可显著减轻炎症和 C 反应蛋白，因此抗坏血酸应作为常规药物的辅助补充剂使用。
