Dethlefs-Canto J, Osses-Barría F, Vergara-Zenteno R, Bustos-Ponce A, Villavicencio-Duarte J
Altamirano Subida Carvallo 211 Valparaíso, Chile
Med Oral Patol Oral Cir Bucal. 2025 Jan 1;30(1):e124-e128. doi: 10.4317/medoral.26893.
Dental extraction is a common procedure in dentistry. It is accompanied by postoperative pain and inflammation. In addition, it decreases bone volume and density. Vitamin C is an antioxidant and cofactor that promotes the synthesis and maturation of collagen, the proliferation and migration of fibroblasts and osteoblasts, accelerating the final phase of inflammation, promoting healing. The objective of this scoping review is to evaluate the effectiveness of vitamin c in dental alveolus healing after extraction and synthesize the available evidence and tits clinical implications.
This review is registered on the Open Science Framework platform (https://osf.io/bstwk/). It was carried out under the PRISMA-ScR protocol, using the question: Is vitamin C effective in alveolar healing in patients undergoing dental extraction? The Pubmed/MEDLINE, Scopus, Web of Science and OPENGREY databases were used. Limiting itself to primary studies.
A total of 287 articles were identified, applying selection criteria, 3 were included. Of a total of 135 patients, 59.8% were administered vitamin C; 46.6% 600 mg, 34.2% 500 mg and 19.2% 1500 mg. A decrease in pain, inflammation, probing depth and mesiodistal length of the socket was observed.
The role of vitamin C is essential for healing, and therefore, bone regeneration after tooth extraction, reducing adverse effects such as pain and inflammation. Its administration is recommended to promote postoperative recovery. More studies are suggested to observe its effects in oral and maxillofacial surgery.
拔牙是牙科常见的操作。拔牙会伴有术后疼痛和炎症。此外，拔牙会减少骨量和骨密度。维生素C是一种抗氧化剂和辅助因子，可促进胶原蛋白的合成与成熟、成纤维细胞和成骨细胞的增殖与迁移，加速炎症的最后阶段，促进愈合。本范围综述的目的是评估维生素C在拔牙后牙槽愈合中的有效性，并综合现有证据及其临床意义。
本综述已在开放科学框架平台（https://osf.io/bstwk/）注册。它是根据PRISMA-ScR方案进行的，问题是：维生素C对拔牙患者的牙槽愈合是否有效？使用了PubMed/MEDLINE、Scopus、科学网和OPENGREY数据库。仅限于纳入原发性研究。
共识别出287篇文章，应用选择标准后，纳入3篇。在总共135名患者中，59.8%接受了维生素C治疗；46.6%接受600毫克，34.2%接受500毫克，19.2%接受1500毫克。观察到疼痛、炎症、探诊深度和牙槽窝近远中长度均有所降低。
维生素C对愈合至关重要，因此对拔牙后的骨再生也很重要，可减少疼痛和炎症等不良反应。建议使用维生素C促进术后恢复。建议开展更多研究以观察其在口腔颌面外科手术中的效果。
