National Institute of Child Health Karachi, Pakistan.
J Ayub Med Coll Abbottabad. 2023 Jul-Sep;35(3):452-456. doi: 10.55519/JAMC-03-12011.
Type-1 diabetes mellitus (T1DM) and autoimmune thyroid disease can occur concomitantly and patients with TIDM have a high risk of other autoimmune conditions like thyroid disease and celiac disease. This study aimed to analyze the association of anti-GAD positive T1DM with anti-thyroid antibodies and celiac disease.
This cross-sectional study was conducted at the Department of Paediatric Endocrinology & Diabetes, National Institute of Child Health, Karachi Pakistan from July 2022 to December 2022. A total of 115 children of both genders aged between 1-18 years having known T1DM were analyzed. Children with chronic kidney disease or chronic liver disease were excluded. Those children were also not included whose parents/caregivers did not wish their children to be part of this research. The blood sample of each child was taken in a sterilized container and sent to an institutional laboratory for biochemical investigations.
In a total of 115 patients, 67 (58.3%) were female and 48 (41.7%) males. The mean age was 8.87±3.43 (ranging between 1.5-17 years). The mean HbA1c was 11.86±7.31%. It was found that anti-GAD IgG was having signification association with celiac disease (p<0.001). Significant correlation of anti-GAD positive antibodies with Ttg-IgG antibodies (correlation coefficient=0.303, p=0.001), thyroid peroxidase antibodies (correlation coefficient=0.228, p=0.001).
High proportions of children with anti-GAD positive T1DM patients were found to have thyroid disorders and celiac disease. A significant correlation was found between anti-GAD positive antibodies, celiac disease and anti-thyroglobulin antibodies.
1 型糖尿病（T1DM）和自身免疫性甲状腺疾病可同时发生，TIDM 患者发生其他自身免疫性疾病（如甲状腺疾病和乳糜泻）的风险较高。本研究旨在分析抗谷氨酸脱羧酶阳性 T1DM 与抗甲状腺抗体和乳糜泻之间的关系。
本横断面研究于 2022 年 7 月至 2022 年 12 月在巴基斯坦卡拉奇国家儿童健康研究所儿科内分泌学和糖尿病科进行。共分析了 115 名年龄在 1-18 岁之间的已知 T1DM 的男女儿童。排除患有慢性肾脏病或慢性肝病的儿童。也不包括那些其父母/照顾者不希望其子女参与这项研究的儿童。每个孩子的血液样本都在一个消毒容器中采集，并送到一个机构实验室进行生化检查。
在总共 115 名患者中，67 名（58.3%）为女性，48 名（41.7%）为男性。平均年龄为 8.87±3.43（范围为 1.5-17 岁）。平均 HbA1c 为 11.86±7.31%。结果发现，抗-GAD IgG 与乳糜泻有显著相关性（p<0.001）。抗-GAD 阳性抗体与 Ttg-IgG 抗体（相关系数=0.303，p=0.001）、甲状腺过氧化物酶抗体（相关系数=0.228，p=0.001）有显著相关性。
发现抗-GAD 阳性 T1DM 患者中存在较高比例的甲状腺疾病和乳糜泻。抗-GAD 阳性抗体、乳糜泻和抗甲状腺球蛋白抗体之间存在显著相关性。
