Lešin Gaćina Dina, Marčinko Darko, Kuzman Tomislav, Škegro Ivan, Vidas Pauk Sania, Škegro Bernarda, Tomić Martina, Bulum Tomislav, Jandroković Sonja
Department of Ophthalmology, Zagreb University Hospital Centre, Zagreb, Croatia.
Department of Psychiatry and Psychological Medicine, Zagreb University Hospital Centre, Zagreb, Croatia.
Curr Med Res Opin. 2024 Apr;40(4):583-590. doi: 10.1080/03007995.2024.2323644. Epub 2024 Mar 8.
Cloninger's psychobiosocial model of personality proposes that consistent patterns of health behavior are determined by the complex interaction of different neurobiological processes of the patient's temperament and character dimensions. Poor medication adherence is a pervasive problem among glaucoma patients and can lead to increased morbidity and disability. The objective of the present study was to investigate the association between Cloninger's personality dimensions and medication adherence among glaucoma patients.
The cross-sectional study was conducted among 113 primary open-angle glaucoma (POAG) patients. The treatment adherence was assessed through a valid and reliable self-administered questionnaire, the Culig Adherence Scale (CAS). Personality dimensions were evaluated using the abbreviated version of the Temperament and Character Inventory-Revised (TCI-140). Statistical analyses were performed using TIBCO Statistica 14.0.1. The study protocol was registered in the DRKS - German Clinical Trials Register; (DRKS-ID: DRKS00022081).
According to CAS, only 39.8% of patients were adherent to glaucoma treatment. Adherence was significantly negatively related only to the character dimension of Self-Transcendence ( < 0.05). No other TCI-140 dimension was significantly associated with medication adherence ( > 0.05).
The results suggest that POAG patients with higher scores on the Self-Transcendent personality dimension are more likely to experience difficulties adhering to medication regimen. The study highlights the importance of a holistic approach to glaucoma treatment, which takes into account not only the biological aspects of disease but also the psychosocial factors that influence patient behavior. Healthcare providers may need to consider glaucoma patients' personality dimensions, beliefs and values when developing treatment plans and strategies to improve medication adherence.
克隆宁格的人格心理生物社会模型提出，健康行为的一致模式是由患者气质和性格维度的不同神经生物学过程的复杂相互作用所决定的。药物依从性差是青光眼患者中普遍存在的问题，可能导致发病率和残疾率增加。本研究的目的是调查克隆宁格人格维度与青光眼患者药物依从性之间的关联。
对113例原发性开角型青光眼（POAG）患者进行了横断面研究。通过一份有效且可靠的自填问卷——库里格依从性量表（CAS）来评估治疗依从性。使用气质和性格问卷修订版（TCI-140）的简化版来评估人格维度。使用TIBCO Statistica 14.0.1进行统计分析。该研究方案已在德国临床试验注册中心（DRKS）注册；（DRKS-ID：DRKS00022081）。
根据CAS，只有39.8%的患者坚持青光眼治疗。依从性仅与自我超越的性格维度显著负相关（<0.05）。没有其他TCI-140维度与药物依从性显著相关（>0.05）。
结果表明，自我超越人格维度得分较高的POAG患者更有可能在坚持药物治疗方案方面遇到困难。该研究强调了青光眼整体治疗方法的重要性，这种方法不仅要考虑疾病的生物学方面，还要考虑影响患者行为的心理社会因素。医疗保健提供者在制定改善药物依从性的治疗计划和策略时，可能需要考虑青光眼患者的人格维度、信念和价值观。
