Department of Ophthalmology, Zagreb University Hospital Center, Zagreb, Croatia.
University of Zagreb, School of Medicine, Zagreb, Croatia.
Eur J Ophthalmol. 2023 Jan;33(1):333-340. doi: 10.1177/11206721221112150. Epub 2022 Jul 5.
This study aimed to evaluate the level of treatment adherence and identify predictors of adherence in glaucoma patients during the coronavirus disease 2019 (COVID-19) pandemic in Zagreb, Croatia.
The cross-sectional study was conducted among primary open-angle glaucoma (POAG) patients at the Department of Ophthalmology, University Hospital Centre Zagreb, between 1st April 2020 and 1st April 2021. The sociodemographic data, clinical, and drug information were recorded. The treatment adherence was assessed through a self-administered questionnaire, the Culig Adherence Scale (CAS). Statistical analyses were performed using TIBCO Statistica™ 14.0.0.
113 POAG patients (48M/65F) with a mean age of 65.89 ± 8.53 years were included in this study. According to the CAS, only 39.8% of patients adhered to topical glaucoma treatment. Educational level was positively related to adherence to treatment (p = 0.022). The main predictors for adherence were the patients' positive attitude towards the drug's effect, family support, and good relationship with the healthcare providers (p < 0.05, respectively). The majority of patients stated forgetfulness as the main reason for skipping drug dosing.
Non-adherence to treatment was prevalent among patients with POAG during the COVID-19 pandemic in Zagreb, Croatia. Personal beliefs and attitudes towards treatment, family support, and patient-healthcare provider relationship were significant predictors of adherence. Special consideration should be given to the whole health system-level strategies targeting the adherence to treatment, especially in crises, in order to achieve positive therapeutic outcomes.The study protocol was registered in the DRKS - German Clinical Trials Register, DRKS-ID: DRKS00022081.
本研究旨在评估克罗地亚萨格勒布市在 2019 年冠状病毒病（COVID-19）大流行期间青光眼患者的治疗依从水平，并确定其影响因素。
这是一项横断面研究，在 2020 年 4 月 1 日至 2021 年 4 月 1 日期间，在萨格勒布大学医院眼科部门对原发性开角型青光眼（POAG）患者进行了研究。记录了患者的社会人口统计学数据、临床和药物信息。通过自我管理问卷、Culig 依从量表（CAS）评估治疗依从性。使用 TIBCO Statistica™ 14.0.0 进行统计分析。
本研究共纳入 113 名 POAG 患者（48 名男性/65 名女性），平均年龄为 65.89 ± 8.53 岁。根据 CAS，只有 39.8%的患者坚持局部使用青光眼药物。教育程度与治疗依从性呈正相关（p = 0.022）。依从性的主要预测因素是患者对药物效果的积极态度、家庭支持和与医疗保健提供者的良好关系（p 值分别为 <0.05）。大多数患者表示健忘是漏服药物的主要原因。
在 COVID-19 大流行期间，克罗地亚萨格勒布市的 POAG 患者普遍存在不遵医嘱治疗的情况。个人对治疗的信念和态度、家庭支持以及患者与医疗保健提供者的关系是影响治疗依从性的重要因素。在整个卫生系统层面，应特别关注针对治疗依从性的策略，尤其是在危机时期，以实现积极的治疗效果。本研究方案已在 DRKS - 德国临床试验注册中心注册，DRKS-ID：DRKS00022081。
