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气溶胶感染拉沙病毒引起的食蟹猴出血热在时间进程中的大体和组织学病变及免疫组织化学染色反应图谱。

An atlas of gross and histologic lesions and immunohistochemical immunoreactivity during the temporal progression of aerosolized Lassa virus induced hemorrhagic fever in cynomolgus macaques.

机构信息

Laboratory of Virology, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, National Institutes of Health (NIH), Hamilton, MT, United States.

Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, United States.

出版信息

Front Cell Infect Microbiol. 2024 Feb 9;14:1341891. doi: 10.3389/fcimb.2024.1341891. eCollection 2024.

DOI:10.3389/fcimb.2024.1341891
PMID:38404292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10884106/
Abstract

Lassa virus (LASV) causes an acute multisystemic hemorrhagic fever in humans known as Lassa fever, which is endemic in several African countries. This manuscript focuses on the progression of disease in cynomolgus macaques challenged with aerosolized LASV and serially sampled for the development and progression of gross and histopathologic lesions. Gross lesions were first noted in tissues on day 6 and persisted throughout day 12. Viremia and histologic lesions were first noted on day 6 commencing with the pulmonary system and hemolymphatic system and progressing at later time points to include all systems. Immunoreactivity to LASV antigen was first observed in the lungs of one macaque on day 3 and appeared localized to macrophages with an increase at later time points to include immunoreactivity in all organ systems. Additionally, this manuscript will serve as a detailed atlas of histopathologic lesions and disease progression for comparison to other animal models of aerosolized Arenaviral disease.

摘要

拉沙病毒（LASV）可引起人类急性全身性出血热，即拉沙热，该病在几个非洲国家流行。本文主要介绍了感染气溶胶化 LASV 的食蟹猴的疾病进展情况，并对其进行了连续采样，以研究大体和组织病理学病变的发展和进展。第 6 天在组织中首次观察到大体病变，并持续至第 12 天。第 6 天开始出现病毒血症和组织病理学病变，首先累及肺部和血液淋巴系统，随后在较晚时间点累及所有系统。在一只猕猴的肺部首次观察到针对 LASV 抗原的免疫反应，最初局限于巨噬细胞，随后在较晚时间点在所有器官系统中均观察到免疫反应。此外，本文还将作为一个详细的组织病理学病变和疾病进展图谱，与其他气溶胶化沙粒病毒病动物模型进行比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58fd/10884106/4bf70f506fe4/fcimb-14-1341891-g010.jpg
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Cell Host Microbe. 2022 Dec 14;30(12):1759-1772.e12. doi: 10.1016/j.chom.2022.10.018. Epub 2022 Nov 17.
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Lassa fever - the road ahead.拉沙热——前路漫漫。
Nat Rev Microbiol. 2023 Feb;21(2):87-96. doi: 10.1038/s41579-022-00789-8. Epub 2022 Sep 12.
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Ribavirin for treating Lassa fever: A systematic review of pre-clinical studies and implications for human dosing.利巴韦林治疗拉沙热：临床前研究的系统评价及其对人体剂量的影响。
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The One Health approach to incident management of the 2019 Lassa fever outbreak response in Nigeria.尼日利亚2019年拉沙热疫情应对事件管理中的“同一健康”方法。
One Health. 2021 Nov 8;13:100346. doi: 10.1016/j.onehlt.2021.100346. eCollection 2021 Dec.
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Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs.联合口服可用批准药物抑制沙粒病毒。
Antimicrob Agents Chemother. 2021 Mar 18;65(4). doi: 10.1128/AAC.01146-20.
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Lassa Fever Induced Hearing Loss: The Neglected Disability of Hemorrhagic Fever.拉沙热致聋：被忽视的出血热致残问题。
Int J Infect Dis. 2020 Nov;100:82-87. doi: 10.1016/j.ijid.2020.08.021. Epub 2020 Aug 11.
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Natural History of Aerosol Induced Lassa Fever in Non‑Human Primates.气溶胶诱导拉沙热在非人灵长类动物中的自然史。
Viruses. 2020 May 29;12(6):593. doi: 10.3390/v12060593.
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