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常规精神科实践中的脑影像学。

Brain Imaging in Routine Psychiatric Practice.

机构信息

Assistant Professor of Psychiatry (Child), Washington University School of Medicine in St. Louis, Missouri.

Professor of Psychiatry, Neurology, Radiology, and Neuroscience at Washington University School of Medicine in St. Louis, Missouri.

出版信息

Mo Med. 2024 Jan-Feb;121(1):37-43.

PMID:38404436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10887461/
Abstract

Technologies in the 21st century provide increasingly detailed and accurate maps of brain structure and function. So why don't psychiatrists order brain imaging on all our patients? Here we briefly review major neuroimaging methods and some of their findings in psychiatry. As clinicians and neuroimaging researchers, we are eager to bring brain imaging into daily clinical practice. However, to be clinically useful, any test in medicine must demonstrate adequate test statistics, and show proven benefits that outweigh its risks and costs. In 2024, beyond certain limited circumstances, we have no imaging tests that can meet those standards to provide diagnosis or guide treatment. This cold fact explains why for most psychiatric patients, neuroimaging is not currently recommended by professional organizations or the National Institute of Mental Health.

摘要

21 世纪的技术为我们提供了越来越详细和精确的大脑结构和功能图谱。那么,为什么精神科医生不在所有患者身上都开脑部影像学检查呢?在这里,我们简要回顾了主要的神经影像学方法及其在精神病学中的部分发现。作为临床医生和神经影像学研究人员,我们渴望将脑成像技术应用于日常临床实践中。然而,要在临床上有用,医学中的任何检测都必须具有足够的统计学意义,并显示出其益处超过风险和成本。到 2024 年,在某些特定情况下,我们还没有任何影像学检测能够达到这些标准,从而提供诊断或指导治疗。这一残酷的事实解释了为什么对于大多数精神科患者来说,神经影像学目前还没有得到专业组织或美国国家精神卫生研究所的推荐。

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本文引用的文献

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A review of resting-state fMRI and its use to examine psychiatric disorders.静息态功能磁共振成像综述及其在精神疾病研究中的应用。
Psychoradiology. 2021 May 11;1(1):42-53. doi: 10.1093/psyrad/kkab003. eCollection 2021 Mar.
2
Better Biomarkers, Faster Drugs, Stronger Models: Progress Towards Precision Psychiatry.更好的生物标志物、更快的药物、更强的模型:迈向精准精神病学的进展。
Mo Med. 2023 Jul-Aug;120(4):292-298.
3
Time of day dependent longitudinal changes in resting-state fMRI.静息态功能磁共振成像中与一天中的时间相关的纵向变化。
Front Neurol. 2023 Jul 5;14:1166200. doi: 10.3389/fneur.2023.1166200. eCollection 2023.
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Understanding Social Determinants of Brain Health During Development.了解发育过程中大脑健康的社会决定因素。
Am J Psychiatry. 2023 Feb 1;180(2):108-110. doi: 10.1176/appi.ajp.20220991.
5
Application of positron emission tomography in psychiatry-methodological developments and future directions.正电子发射断层扫描在精神病学中的应用——方法学的发展与未来方向。
Transl Psychiatry. 2022 Jun 14;12(1):248. doi: 10.1038/s41398-022-01990-2.
6
Brain ventricular volume changes in schizophrenia. A narrative review.精神分裂症患者脑室容积的变化。一篇叙述性综述。
Neurosci Lett. 2021 Aug 10;759:136065. doi: 10.1016/j.neulet.2021.136065. Epub 2021 Jun 16.
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Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.对超过 40000 例双相情感障碍病例的全基因组关联研究为其潜在生物学机制提供了新的见解。
Nat Genet. 2021 Jun;53(6):817-829. doi: 10.1038/s41588-021-00857-4. Epub 2021 May 17.
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Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group.阿尔茨海默病的临床诊断:国际工作组的建议。
Lancet Neurol. 2021 Jun;20(6):484-496. doi: 10.1016/S1474-4422(21)00066-1. Epub 2021 Apr 29.
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Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Dec;6(12):1135-1144. doi: 10.1016/j.bpsc.2020.12.002. Epub 2020 Dec 16.
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The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia.美国精神病学协会《精神分裂症患者治疗实践指南》。
Focus (Am Psychiatr Publ). 2020 Oct;18(4):493-497. doi: 10.1176/appi.focus.18402. Epub 2020 Nov 5.