Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology, Hangzhou, China.
Front Immunol. 2024 Feb 9;15:1361194. doi: 10.3389/fimmu.2024.1361194. eCollection 2024.
Natural Killer (NK) cells, intrinsic to the innate immune system, are pivotal in combating cancer due to their independent cytotoxic capabilities in antitumor immune response. Unlike predominant treatments that target T cell immunity, the limited success of T cell immunotherapy emphasizes the urgency for innovative approaches, with a spotlight on harnessing the potential of NK cells. Despite tumors adapting mechanisms to evade NK cell-induced cytotoxicity, there is optimism surrounding Chimeric Antigen Receptor (CAR) NK cells. This comprehensive review delves into the foundational features and recent breakthroughs in comprehending the dynamics of NK cells within the tumor microenvironment. It critically evaluates the potential applications and challenges associated with emerging CAR-NK cell therapeutic strategies, positioning them as promising tools in the evolving landscape of precision medicine. As research progresses, the unique attributes of CAR-NK cells offer a new avenue for therapeutic interventions, paving the way for a more effective and precise approach to cancer treatment.
自然杀伤 (NK) 细胞是固有免疫系统的重要组成部分，由于其在抗肿瘤免疫反应中具有独立的细胞毒性能力，因此在对抗癌症方面发挥着关键作用。与主要针对 T 细胞免疫的治疗方法不同，T 细胞免疫疗法的有限成功强调了创新方法的紧迫性，重点是利用 NK 细胞的潜力。尽管肿瘤会适应机制来逃避 NK 细胞诱导的细胞毒性，但人们对嵌合抗原受体 (CAR) NK 细胞持乐观态度。这篇全面的综述深入探讨了 NK 细胞在肿瘤微环境中的基础特征和最新突破。它批判性地评估了新兴的 CAR-NK 细胞治疗策略的潜在应用和挑战，将其定位为精准医学不断发展的景观中的有前途的工具。随着研究的进展，CAR-NK 细胞的独特属性为治疗干预提供了新途径，为癌症治疗的更有效和更精确方法铺平了道路。
