对市售蛇毒抗毒素的分析显示，某些产品中内毒素含量很高。
Analysis of commercially available snake antivenoms reveals high contents of endotoxins in some products.
作者信息
Solano Gabriela, Ainsworth Stuart, Sánchez Adriana, Villalta Mauren, Sánchez Paola, Durán Gina, Gutiérrez José María, León Guillermo
机构信息
Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.
Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, L3 5RF, UK.
出版信息
Toxicon X. 2024 Feb 15;21:100187. doi: 10.1016/j.toxcx.2024.100187. eCollection 2024 Mar.
As injectable therapeutics, snake antivenoms must meet specifications for endotoxin content. The amebocyte lysate (LAL) test was used to evaluate the endotoxin content in several commercially available antivenoms released for clinical use. It was found that some products have endotoxin concentrations higher than the accepted limit for these contaminants. These results emphasize the need to include endotoxin determination as part of the routine evaluation of antivenoms by manufacturers and regulatory agencies.
作为注射用治疗剂，蛇毒抗毒素必须符合内毒素含量的规范。采用鲎试剂（LAL）试验评估了几种市售临床用抗毒素的内毒素含量。结果发现，一些产品的内毒素浓度高于这些污染物的可接受限度。这些结果强调了制造商和监管机构在抗毒素常规评估中纳入内毒素测定的必要性。
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