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探索阿拉伯联合酋长国糖尿病与乳腺癌之间的关系。

Exploring the Relationship Between Diabetes and Breast Cancer in the United Arab Emirates.

作者信息

Alharmoodi Fatima, Al Ameri Mouza A, Alblooshi Mohammed, Shanbhag Nandan M, Almheiri Mariam H, Bin Sumaida Abdulrahman

机构信息

General Surgery, Tawam Hospital, Al Ain, ARE.

Oncology, Tawam Hospital, Al Ain, ARE.

出版信息

Cureus. 2024 Feb 23;16(2):e54787. doi: 10.7759/cureus.54787. eCollection 2024 Feb.

Abstract

Introduction This study delves into the complex interplay between diabetes and breast cancer within the United Arab Emirates (UAE), a subject of considerable global health concern. Given the increasing incidence of both diseases worldwide, this research investigates explicitly the potential influence of diabetes on the staging of breast cancer. The UAE, mirroring global trends, has experienced a surge in both conditions attributed to a blend of genetic, environmental, and lifestyle factors. The core objective of this investigation is to explore the link between diabetes and the stage at which breast cancer is diagnosed in UAE patients. Material and method To conduct this study, data were extracted from an extensive medical database consisting of anonymized records about breast cancer patients and their comorbid conditions. The research encompassed adult patients of all genders, all of whom had been definitively diagnosed with breast cancer. The data was analyzed using a suite of Python libraries, including Pandas, NumPy, SciPy, Scikit-learn, Matplotlib, and Seaborn. Descriptive and inferential statistical methods were employed, focusing on the Chi-Square test and logistic regression analysis to evaluate the relationship between diabetes and the stages of breast cancer, considering other comorbidities as well. Results The analysis included 131 breast cancer patients, predominantly female (98.47%), with an average age of 54.2 years. Among these patients, 22.14% were diabetic. The prevalence of other comorbidities, such as dyslipidemia, hypertension, and hypothyroidism, was also recorded. The Chi-Square test indicated no significant correlation between diabetes and the stages of breast cancer (χ² = 3.07, p = 0.381). Stage II was the most frequently diagnosed, irrespective of the presence or absence of diabetes. Conclusion In conclusion, this study finds no substantial link between diabetes and the stage of breast cancer diagnosis among patients in the UAE after adjusting for age and other comorbid conditions. These results underscore the need for early breast cancer detection approaches that are not exclusively dependent on the diabetic status of the patients. However, limitations such as the retrospective cohort design and the relatively small sample size highlight the necessity for further comprehensive studies. Such research would deepen the understanding of the relationship between diabetes and breast cancer and contribute to the advancement of breast cancer healthcare in the UAE.

摘要

引言 本研究深入探讨了阿拉伯联合酋长国(UAE)糖尿病与乳腺癌之间复杂的相互作用,这是一个受到全球健康广泛关注的课题。鉴于全球范围内这两种疾病的发病率不断上升,本研究明确调查了糖尿病对乳腺癌分期的潜在影响。与全球趋势一致,由于遗传、环境和生活方式等多种因素的综合作用,阿联酋这两种疾病的发病率均出现了激增。本调查的核心目标是探索阿联酋患者糖尿病与乳腺癌诊断分期之间的联系。

材料与方法 为开展本研究,从一个广泛的医学数据库中提取数据,该数据库包含有关乳腺癌患者及其合并症的匿名记录。该研究涵盖了所有性别的成年患者,他们均已被明确诊断为乳腺癌。使用一系列Python库对数据进行分析,包括Pandas、NumPy、SciPy、Scikit-learn、Matplotlib和Seaborn。采用描述性和推断性统计方法,重点运用卡方检验和逻辑回归分析来评估糖尿病与乳腺癌分期之间的关系,并同时考虑其他合并症。

结果 分析纳入了131例乳腺癌患者,其中女性占主导(98.47%),平均年龄为54.2岁。在这些患者中,22.14%患有糖尿病。还记录了其他合并症的患病率,如血脂异常、高血压和甲状腺功能减退。卡方检验表明糖尿病与乳腺癌分期之间无显著相关性(χ² = 3.07,p = 0.381)。无论是否患有糖尿病,II期是最常诊断出的阶段。

结论 总之,本研究发现,在调整年龄和其他合并症因素后,阿联酋患者中糖尿病与乳腺癌诊断分期之间没有实质性联系。这些结果强调了乳腺癌早期检测方法的必要性,这些方法不应仅仅依赖于患者的糖尿病状况。然而,诸如回顾性队列设计和相对较小的样本量等局限性凸显了进一步开展全面研究的必要性。此类研究将加深对糖尿病与乳腺癌之间关系的理解,并有助于推动阿联酋乳腺癌医疗保健的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bc/10891308/21c4ed422c8f/cureus-0016-00000054787-i01.jpg

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