Member B, Helson L, Helson C, Erlandson R, Hajdu S I
Anticancer Res. 1985 Sep-Oct;5(5):559-64.
The clinical characteristics and response to therapy of a patient with meningeal sarcoma, one of four patients over a twenty-five year period at Memorial Sloan-Kettering Cancer Center, are described. The light and electron microscopic characteristics of the primary tumor and as a heterotransplant in nude mice showed minimal differences. The tumor was resistant to conventional chemotherapeutic agents, both in the patient, in vitro as a cell culture and ex vivo as a heterotransplant. Only a combination of L-phenylalanine mustard and dianhydrogalactitol produced a limited response in both the patient and the mice. This combination may have some utility in future cases.
