Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Division of Pathology, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Head Neck. 2024 Oct;46(10):2389-2397. doi: 10.1002/hed.27709. Epub 2024 Feb 26.
This study aimed to examine treatment outcomes and postoperative complications associated with salvage skull base surgery following radical proton beam therapy (PBT).
Nine patients who underwent salvage skull base surgery following curative PBT as the initial treatment at our institution between September 2002 and May 2023 were retrospectively reviewed.
The cohort comprised four males and five females with a mean age of 48.1 years. The average proton dose administered during initial therapy was 68.5 Gy (relative biological effectiveness). Among the salvage surgeries, eight were anterior skull base surgeries, and one was an anterior middle skull base surgery. No local recurrences or perioperative deaths were observed. Postoperative complications occurred in three patients (33.3%), all experiencing surgical site infections, with one also having cerebrospinal fluid leakage.
The study demonstrates that salvage skull base surgery after PBT effectively achieves local control and safety in patients with recurrent sinonasal malignancies.
本研究旨在探讨根治性质子束治疗（PBT）后行挽救性颅底手术的治疗效果和术后并发症。
回顾性分析 2002 年 9 月至 2023 年 5 月我院 9 例接受根治性 PBT 作为初始治疗后行挽救性颅底手术的患者。
本队列包括 4 名男性和 5 名女性，平均年龄为 48.1 岁。初始治疗时给予的质子平均剂量为 68.5Gy（相对生物效应）。挽救性手术中，8 例为前颅底手术，1 例为前中颅底手术。无局部复发或围手术期死亡病例。3 例（33.3%）患者发生术后并发症，均为手术部位感染，其中 1 例合并脑脊液漏。
本研究表明，对于复发性鼻腔鼻窦恶性肿瘤患者，PBT 后行挽救性颅底手术可有效实现局部控制和安全性。
