生胃酮和去甘草甜素的甘草对大鼠胃黏膜前列腺素的体外合成几乎没有影响。
Carbenoxolone and deglycyrrhized liquorice have little or no effect on prostanoid synthesis by rat gastric mucosa ex vivo.
作者信息
Bennett A, Melhuish P B, Stamford I F
出版信息
Br J Pharmacol. 1985 Nov;86(3):693-5. doi: 10.1111/j.1476-5381.1985.tb08947.x.
Abstract
Rats were given either carbenoxolone 50 mg kg-1, deglycyrrhized liquorice 1 g kg-1 or vehicle by gastric tube. The doses were repeated 16 h later, and the stomachs removed after another 2 h. The amounts of prostaglandin E (PGE), 6-keto-PGF1 alpha and thromboxane B2, measured by radioimmunoassay in extracts of the gastric corpus and antrum mucosa, were similar in the treated animals and the controls. We conclude that in rats, carbenoxolone and deglycyrrhized liquorice may exert their anti-ulcer effect by a non-prostaglandin mechanism. This contrasts with the mechanism through to occur in man with carbenoxolone.
摘要
给大鼠经胃管分别给予50毫克/千克的生胃酮、1克/千克的去甘草酸甘草或赋形剂。16小时后重复给药剂量，再过2小时后取出胃。通过放射免疫分析法测定胃体和胃窦黏膜提取物中前列腺素E（PGE）、6-酮-前列腺素F1α和血栓素B2的含量，结果显示治疗组动物和对照组相似。我们得出结论，在大鼠中，生胃酮和去甘草酸甘草可能通过非前列腺素机制发挥其抗溃疡作用。这与人类服用生胃酮时发生作用的机制不同。
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