磺基糖肽对人胃窦黏膜内源性前列腺素合成的影响。

Effects of sulglycotide on endogenous prostaglandin synthesis in human antral mucosa.

作者信息

Calabrò A, Orsini B, Milani S, Psilogenis M, Surrenti C

机构信息

Department of Clinical Pathophysiology, University of Florence, Italy.

出版信息

Pharmacol Res. 1992 Dec;26(4):403-7. doi: 10.1016/1043-6618(92)90239-8.

DOI:10.1016/1043-6618(92)90239-8

PMID:1294942

Abstract

The effect of sulglycotide, a polysulphated glycopeptide isolated from pig duodenum, on PGE2, 6-ketoPGF1 alpha and TxB2 production from isolated biopsy specimens of human antral mucosa was investigated in vitro, in comparison with carbenoxolone. In addition to a tendency toward increased PGE2 production just short of statistical significance, both sulglycotide and carbenoxolone significantly increased 6-ketoPGF1 alpha accumulation in the incubation medium. TxB2 levels were not significantly modified by the two drugs. Therefore, changes in the prostanoid production by human antral mucosa could, at least partially account for the cytoprotective effects of sulglycotide in man.

摘要

将从猪十二指肠分离出的多硫酸化糖肽舒糖肽与甘珀酸相比，在体外研究了其对人胃窦黏膜活检标本中前列腺素E2（PGE2）、6-酮前列腺素F1α（6-ketoPGF1α）和血栓素B2（TxB2）生成的影响。除了PGE2生成有增加趋势但未达到统计学显著意义外，舒糖肽和甘珀酸均显著增加了孵育培养基中6-ketoPGF1α的积聚。两种药物对TxB2水平均无显著影响。因此，人胃窦黏膜前列腺素生成的变化可能至少部分解释了舒糖肽对人的细胞保护作用。