Selvander Madeleine, Alexander Jan, Guenot Diego
Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Sundets Ögonläkare, Helsingborg, Sweden.
Curr Eye Res. 2024 Jun;49(6):624-630. doi: 10.1080/02713683.2024.2314602. Epub 2024 Feb 26.
The prevalence of choroidal naevi is common and has been found to be up to 10%. Little is known regarding the optical properties of choroidal naevi. A novel hyperspectral eye fundus camera was used to investigate choroidal naevi's optical density spectra in the retina.
In an ophthalmology clinic setting, patients with choroidal naevi were included in the study. Visual acuity and pressure were tested. Following mydriatics, optical coherence tomography and fundus photography were taken as a reference, after which a hyperspectral image with 12 nm spectral resolution at 450-700 nm was taken. The optical density spectra was measured across the area of the naevus.
Nine patients with 11 naevi were examined. The visual acuity was not affected by any of the naevi. All the naevi were flat as measured either with the optical coherence tomography and/or on inspection, and only one naevi had a risk factor (orange pigmentation). The Wasserstein distance between the background and the naevi was higher at 695 nm compared to 555 nm ( = .002). The naevi could be grouped into three clusters based on the extracted optical density spectra.
Choroidal naevi are better visible in longer wavelengths compared to shorter wavelengths. This finding can be used to contour and follow choroidal naevi. Choroidal naevi expose different optical density spectra that can be grouped into three different clusters. One of these clusters has an optical density spectra resembling the absorption spectra of lipofuscin, which may indicate the content of this pigment.
脉络膜痣的患病率很高，已发现高达10%。关于脉络膜痣的光学特性知之甚少。一种新型高光谱眼底相机被用于研究脉络膜痣在视网膜中的光密度光谱。
在眼科诊所环境中，患有脉络膜痣的患者被纳入研究。测试视力和眼压。使用散瞳剂后，以光学相干断层扫描和眼底摄影作为参考，之后拍摄450 - 700nm光谱分辨率为12nm的高光谱图像。在痣的区域测量光密度光谱。
对9名患者的11个脉络膜痣进行了检查。视力未受任何痣的影响。通过光学相干断层扫描和/或检查测量，所有痣均为扁平状，只有一个痣有风险因素（橙色色素沉着）。与555nm相比，在695nm处背景与痣之间的瓦瑟斯坦距离更高（P = 0.002）。根据提取的光密度光谱，痣可分为三个簇。
与较短波长相比，脉络膜痣在较长波长下更易见。这一发现可用于勾勒和跟踪脉络膜痣。脉络膜痣呈现出不同的光密度光谱，可分为三个不同的簇。其中一个簇的光密度光谱类似于脂褐素的吸收光谱，这可能表明该色素的含量。
