Gordon Stefan B, Nadolski Amy C
VCA Emergency Animal Hospital & Referral Center, San Diego, California, USA.
J Vet Emerg Crit Care (San Antonio). 2024 Mar-Apr;34(2):179-185. doi: 10.1111/vec.13363. Epub 2024 Feb 26.
To describe the medical management and outcome of a dog suffering severe hydrogen peroxide toxicity.
A 3-year-old neutered female Bichon Frise was presented to an emergency and referral practice after ingestion of 10-20 mL/kg 3% hydrogen peroxide. On presentation, the dog was obtunded, was tachypneic, and had severe gastric tympany. Abdominal radiographs revealed pneumoperitoneum, gastric pneumatosis, and hepatic venous gas. The dog was managed conservatively with supportive care and oxygen therapy. Repeat radiographs 6 hours later showed complete resolution of all gas inclusions. While hospitalized, the dog developed severe hematemesis, and abdominal ultrasound revealed severe gastric wall thickening. Subsequent endoscopy confirmed severe gastric mucosal necrosis without evidence of deeper ulceration and relatively mild petechiation of the esophagus. The dog was ultimately discharged after 5 days of hospitalization and continued to do well at home. Recheck ultrasound 5 weeks postdischarge showed normal gastric wall appearance.
To the authors' knowledge, this is the first reported case of pneumoperitoneum secondary to hydrogen peroxide toxicity and the first description of the clinical course of severe toxicity in dogs.
描述一只患有严重过氧化氢中毒犬的医疗处理及预后情况。
一只3岁已绝育的雌性比熊犬在摄入10 - 20毫升/千克的3%过氧化氢后被送至一家急诊转诊机构。就诊时，该犬意识迟钝、呼吸急促且有严重的胃鼓胀。腹部X光片显示有气腹、胃壁积气和肝静脉积气。该犬接受了支持治疗和氧疗的保守处理。6小时后复查X光片显示所有气体均完全消散。住院期间，该犬出现严重呕血，腹部超声显示胃壁严重增厚。随后的内窥镜检查证实胃黏膜严重坏死，但未发现更深层溃疡的迹象，且食管有相对较轻的瘀点。该犬住院5天后最终出院，在家中情况持续良好。出院5周后的复查超声显示胃壁外观正常。
据作者所知，这是首例报道的继发于过氧化氢中毒的气腹病例，也是对犬严重中毒临床过程的首次描述。
