Department of Ophthalmology, Istanbul Kartal Doctor Lütfi Kırdar City Hospital, Semsi Denizer Street, E-5, 34890, Kartal, Istanbul, Turkey.
Department of Rheumatology, Istanbul Kartal Doctor Lütfi Kırdar City Hospital, Istanbul, Turkey.
Int Ophthalmol. 2024 Feb 26;44(1):113. doi: 10.1007/s10792-024-02950-z.
To evaluate anterior and posterior segment parameters in the eyes of patients with systemic sclerosis (SSc) and examine the effect of disease and disease subtypes on these parameters.
This cross-sectional study included 54 eyes of 27 SSc patients and 54 eyes of 27 age- and sex-matched healthy controls. In addition to a complete ophthalmologic examination, all patients were examined using a Scheimpflug camera, specular microscopy, and spectral domain optical coherence tomography.
The mean age of the patients was 52.5 ± 11.4 years and 19 patients were female. Anterior chamber volume, central corneal thickness, and central macular thickness (CMT) were significantly lower in the eyes of SSc patients compared to healthy controls (p = 0.01, p = 0.03, and p = 0.006, respectively). When evaluated according to SSc subtype, CMT was lower in diffuse SSc patients (p = 0.001), while mean retinal nerve fiber layer (RNFL) and inferior quadrant RNFL values were lower in limited SSc (p = 0.003 and p = 0.005, respectively).
In the eyes of patients with SSc, some ocular parameters may show decreases compared to healthy individuals, presumably secondary to disease-related vasculopathy and fibrosis. CMT and RNFL parameters may be affected differently according to disease subtype.
评估系统性硬化症（SSc）患者眼前段和后段参数，并研究疾病和疾病亚型对这些参数的影响。
本横断面研究纳入了 27 例 SSc 患者的 54 只眼和 27 名年龄、性别相匹配的健康对照者的 54 只眼。除了全面的眼科检查外，所有患者均使用Scheimpflug 相机、共焦显微镜和频域光相干断层扫描进行检查。
患者的平均年龄为 52.5±11.4 岁，19 名为女性。与健康对照组相比，SSc 患者的前房容积、中央角膜厚度和中央黄斑厚度（CMT）显著降低（p=0.01、p=0.03 和 p=0.006）。根据 SSc 亚型评估时，弥漫性 SSc 患者的 CMT 更低（p=0.001），而局限性 SSc 患者的平均视网膜神经纤维层（RNFL）和下象限 RNFL 值更低（p=0.003 和 p=0.005）。
与健康个体相比，SSc 患者的一些眼部参数可能会降低，推测这与疾病相关的血管病变和纤维化有关。CMT 和 RNFL 参数可能根据疾病亚型而受到不同的影响。
