Ophthalmology Department, Istanbul Kartal Doctor Lütfi Kırdar City Hospital, Istanbul, Turkey.
Gastroenterology Department, Istanbul Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey.
Photodiagnosis Photodyn Ther. 2021 Jun;34:102214. doi: 10.1016/j.pdpdt.2021.102214. Epub 2021 Feb 12.
To evaluate the eyes of adult celiac disease (CD) patients and investigate the association between these ocular parameters with celiac specific antibodies and duration of gluten free diet (GFD).
This cross-sectional study included 72 eyes of 36 CD patients (18-51 years of age) and 70 eyes of 35 age- and sex-matched healthy controls. In addition to a complete ophthalmologic examination, all patients were scanned by a Scheimpflug camera, specular microscopy and spectral domain optical coherence tomography.
Endothelial cell density (ECD), anterior chamber angle (ACA) degrees, anterior chamber depth (ACD), anterior chamber volume (ACV) and central macular thickness (CMT) values were lower in CD patients as compared with control group (p values = 0.038, 0.024, 0.002, 0.038 and 0.046 respectively). ECD and CMT were lower in celiac patients whom endomysial antibodies (EMA) IgA were positive (p = 0.001, p = 0.042 respectively). Tissue transglutaminase IgA antibody (anti tTG IgA) was weakly positively correlated (p > 0.05) with ACD, and positively (r = 0.319; p < 0.05) correlated with ACV. As the duration of compliance to the diet increased in the celiac group the mean and inferior retinal nerve fiber layer (RNFL) thickness decreased (p = 0.035, p = 0.008 respectively). Mean, inferior and temporal RNFL thicknesses were lower in celiac patients whose duration of GFD was longer than 5 years (p < 0.05).
Decreases in ECD, ACA degree, ACD, ACV and CMT can occur in CD patients. In adult celiac patients; ECD, CMT might be effected in the presence of positive EMA, and ACD, ACV might be effected in the presence of higher anti tTG IgA titer. Adult celiac patients who had longer duration of GFD may have thinner RNFL. RNFL may be thinner in celiac patients who comply with GFD for more than 5 years.
评估成人乳糜泻（CD）患者的眼部情况，并研究这些眼部参数与乳糜泻特异性抗体和无麸质饮食（GFD）持续时间之间的关系。
本横断面研究纳入了 36 名 CD 患者（18-51 岁）的 72 只眼和 35 名年龄和性别匹配的健康对照者的 70 只眼。除了全面的眼科检查外，所有患者均接受了 Scheimpflug 相机、共焦显微镜和谱域光学相干断层扫描检查。
与对照组相比，CD 患者的角膜内皮细胞密度（ECD）、前房角（ACA）度数、前房深度（ACD）、前房容积（ACV）和中央黄斑厚度（CMT）值较低（p 值分别为 0.038、0.024、0.002、0.038 和 0.046）。ECD 和 CMT 在 EMA IgA 阳性的乳糜泻患者中较低（p = 0.001，p = 0.042）。组织转谷氨酰胺酶 IgA 抗体（抗 tTG IgA）与 ACD 呈弱正相关（p > 0.05），与 ACV 呈正相关（r = 0.319；p < 0.05）。随着乳糜泻组患者饮食依从性的增加，平均和下方视网膜神经纤维层（RNFL）厚度降低（p = 0.035，p = 0.008）。GFD 持续时间超过 5 年的乳糜泻患者的平均、下方和颞侧 RNFL 厚度较低（p < 0.05）。
CD 患者可能出现 ECD、ACA 度数、ACD、ACV 和 CMT 降低。在成年乳糜泻患者中，ECD、CMT 可能在 EMA 阳性时受到影响，而 ACD、ACV 可能在更高的抗 tTG IgA 滴度时受到影响。GFD 持续时间较长的成年乳糜泻患者的 RNFL 可能较薄。遵循 GFD 超过 5 年的乳糜泻患者的 RNFL 可能较薄。
