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RBP-J 调节循环 Ly6C 单核细胞的稳态和功能。

RBP-J regulates homeostasis and function of circulating Ly6C monocytes.

机构信息

Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China.

Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.

出版信息

Elife. 2024 Feb 26;12:RP88135. doi: 10.7554/eLife.88135.

DOI:10.7554/eLife.88135
PMID:38407952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10942619/
Abstract

Notch-RBP-J signaling plays an essential role in the maintenance of myeloid homeostasis. However, its role in monocyte cell fate decisions is not fully understood. Here, we showed that conditional deletion of transcription factor RBP-J in myeloid cells resulted in marked accumulation of blood Ly6C monocytes that highly expressed chemokine receptor CCR2. Bone marrow transplantation and parabiosis experiments revealed a cell-intrinsic requirement of RBP-J for controlling blood Ly6CCCR2 monocytes. RBP-J-deficient Ly6C monocytes exhibited enhanced capacity competing with wildtype counterparts in blood circulation. In accordance with alterations of circulating monocytes, RBP-J deficiency led to markedly increased population of lung tissues with Ly6C monocytes and CD16.2 interstitial macrophages. Furthermore, RBP-J deficiency-associated phenotypes could be genetically corrected by further deleting in myeloid cells. These results demonstrate that RBP-J functions as a crucial regulator of blood Ly6C monocytes and thus derived lung-resident myeloid populations, at least in part through regulation of CCR2.

摘要

Notch-RBP-J 信号通路在维持骨髓细胞稳态中发挥着重要作用。然而，其在单核细胞细胞命运决策中的作用尚不完全清楚。在这里，我们发现转录因子 RBP-J 在骨髓细胞中的条件性缺失导致血液 Ly6C 单核细胞的显著积累，这些细胞高表达趋化因子受体 CCR2。骨髓移植和联体共生实验揭示了 RBP-J 对控制血液 Ly6CCCR2 单核细胞的细胞内在需求。RBP-J 缺陷型 Ly6C 单核细胞表现出增强的与野生型单核细胞在血液循环中竞争的能力。与循环单核细胞的变化一致，RBP-J 缺陷导致肺组织中 Ly6C 单核细胞和 CD16.2 间质巨噬细胞的数量明显增加。此外，RBP-J 缺陷相关表型可以通过进一步在骨髓细胞中缺失来遗传纠正。这些结果表明，RBP-J 作为血液 Ly6C 单核细胞的关键调节因子，从而调节肺驻留的髓样细胞群，至少部分是通过调节 CCR2 来发挥作用的。

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A non-classical monocyte-derived macrophage subset provides a splenic replication niche for intracellular Salmonella.一种非经典单核细胞衍生的巨噬细胞亚群为细胞内沙门氏菌提供了脾脏复制龛位。
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