Imoto S, Yahata A, Kosaka M, Kamada S, Takeuchi M, Shinpo K, Sudo J, Tanabe T
J Toxicol Sci. 1985 Aug;10 Suppl 1:105-22. doi: 10.2131/jts.10.supplementi_105.
A peri- and postnatal study of halopredone acetate (THS-201), a synthetic corticosteroid, was carried out using Jcl: Wistar rats. Pregnant rats were treated subcutaneously in doses of 0.05, 0.4, 3.2 and 25.6 mg/kg/day, from day 17 of gestation to day 21 after delivery. All pregnant rats were allowed to litter naturally, and the postnatal development of offsprings was observed. The results obtained from the present study were as follows. No influences of THS-201 administration were observed on gestation, delivery and lactation of dams. THS-201 administration did not have any influences on viability and development, various functions such as reflex response, learning and reproductive performance of F1 generation, and further on development of F2 generation. Therefore, it was concluded that the non-effect dose of THS-201 for the reproduction of dams and development of F1 generation was 25.6 mg/kg/day.
使用Jcl:Wistar大鼠对合成皮质类固醇醋酸卤泼尼龙（THS - 201）进行了围产期和产后研究。从妊娠第17天至产后第21天，对怀孕大鼠进行皮下注射，剂量分别为0.05、0.4、3.2和25.6mg/kg/天。所有怀孕大鼠均自然产仔，并观察后代的产后发育情况。本研究获得的结果如下。未观察到给予THS - 201对母鼠的妊娠、分娩和哺乳有影响。给予THS - 201对F1代的活力和发育、各种功能（如反射反应、学习和生殖性能）以及F2代的进一步发育均无任何影响。因此，得出结论，THS - 201对母鼠繁殖和F1代发育的无作用剂量为25.6mg/kg/天。
