Imoto S, Yahata A, Kosaka M, Kamada S, Takeuchi M, Shinpo K, Sudo J, Tanabe T
J Toxicol Sci. 1985 Aug;10 Suppl 1:71-81. doi: 10.2131/jts.10.supplementi_71.
A fertility study of halopredone acetate (THS-201), a synthetic corticosteroid, was carried out using Jcl: Wistar rats. Male rats were treated subcutaneously for 63 days before mating and throughout mating, and female rats were treated subcutaneously for 14 days before mating and until day 7 of gestation, in doses of 0.04, 0.2, 1.0 and 5.0 mg/kg/day. Male and female rats in the same dose were mated. All of the pregnant rats were killed on day 20 of gestation and their fetuses were examined morphologically. The results obtained from the present study were as follows. A decrease in body weight gain was observed in male rats of 1.0 and 5.0 mg/kg groups, compared to the vehicle control group. In female rats of 5.0 mg/kg group, a decrease in body weight gain during gestation period was observed. However, no influences attributable to THS 201 administration were observed on the fertility and fetal development. These results indicated that the non-effect dose of THS-201 for the fertility of rats and fetal development was 5.0 mg/kg/day.
使用Jcl:Wistar大鼠对合成皮质类固醇醋酸卤泼尼龙（THS - 201）进行了生育力研究。雄性大鼠在交配前皮下注射63天并持续整个交配期，雌性大鼠在交配前皮下注射14天并持续至妊娠第7天，剂量分别为0.04、0.2、1.0和5.0毫克/千克/天。相同剂量的雄性和雌性大鼠进行交配。所有妊娠大鼠在妊娠第20天处死，并对其胎儿进行形态学检查。本研究获得的结果如下。与溶剂对照组相比，1.0和5.0毫克/千克组的雄性大鼠体重增加减少。在5.0毫克/千克组的雌性大鼠中，观察到妊娠期体重增加减少。然而，未观察到醋酸卤泼尼龙给药对生育力和胎儿发育有任何影响。这些结果表明，醋酸卤泼尼龙对大鼠生育力和胎儿发育的无作用剂量为5.0毫克/千克/天。
