Kuhn M, Widder W, Gartmann J, Hartmann G
Schweiz Med Wochenschr. 1985 Sep 28;115(39):1365-7.
In a 26-year-old patient admitted to the emergency ward with acute abdomen, all the symptoms--nausea, vomiting, indeterminate abdominal pain, constipation, renal failure, polyuria and polydipsia--could be explained by calcium intoxication syndrome. Investigation revealed generalized sarcoidosis. Under medical treatment with prednisone all the pathologic findings rapidly regressed. The pathogenesis of hypercalcemia in sarcoidosis, and particularly the disorder of vitamin D metabolism with raised levels of 1,25-dihydroxycholecalciferol, are discussed.
一名26岁的患者因急腹症被收入急诊病房，其所有症状——恶心、呕吐、不明原因的腹痛、便秘、肾衰竭、多尿和烦渴——都可以用钙中毒综合征来解释。检查发现患者患有全身性结节病。在接受泼尼松药物治疗后，所有病理表现迅速消退。本文讨论了结节病中高钙血症的发病机制，尤其是1,25-二羟胆钙化醇水平升高导致的维生素D代谢紊乱。
