Podwysocki B
Katedra i Zakład Analytiki Medycznej Akademii Medycznej, Wrocławiu.
Postepy Hig Med Dosw. 1994;48(2):193-206.
Sarcoidosis is a multisystemic disease of unknown etiology with characteristic picture of immunological disorders. As an unfavourable course of the disease both fibrosis and abnormal calcium metabolism may occur. The last one is reflected by hypercalcemia and/or hypercalcuria. In this paper the recent advances in the explanation of pathogenesis of impaired calcium homeostasis in patients with sarcoidosis have been reviewed. The evaluation of calcium concentration in urine and plasma, production rate of vitamin D metabolites, isolation and structural identification of 1,25 dihydroxy vitamin D3 as well as regulation of its synthesis by pulmonary alveolar macrophages from patients with sarcoidosis have been discussed. Subsequently, vitamin D metabolism by sarcoid lymph node and application of steroids and chloroquine for the treatment of disturbed calcium metabolism has been presented.
结节病是一种病因不明的多系统疾病，具有免疫紊乱的特征性表现。作为疾病的不良病程，可能会出现纤维化和钙代谢异常。后者表现为高钙血症和/或高钙尿症。本文综述了结节病患者钙稳态受损发病机制解释方面的最新进展。讨论了对尿液和血浆中钙浓度的评估、维生素D代谢产物的生成率、1,25-二羟基维生素D3的分离和结构鉴定，以及结节病患者肺泡巨噬细胞对其合成的调节。随后，介绍了结节病淋巴结的维生素D代谢以及类固醇和氯喹在治疗钙代谢紊乱中的应用。
