Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, 40705, Taiwan.
School of Medicine, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
Sci Rep. 2024 Feb 26;14(1):4607. doi: 10.1038/s41598-024-55352-7.
Hepatitis C virus (HCV) infection is prevalent in patients with type 2 diabetes mellitus (DM). We aimed to investigate whether HCV antibody (Ab) seropositivity is associated with diabetic micro- and macro-vascular diseases. In this hospital-based cross-sectional study, we retrospectively collected data from patients who participated in the diabetes pay-for-performance program and underwent HCV Ab screening in the annual comprehensive assessment between January 2021 and March 2022. We examined the relationships of HCV Ab seropositivity with the spot urinary albumin-to-creatinine ratio (UACR) and ankle-brachial index (ABI) in patients aged ≥ 50 years with type 2 DM. A total of 1758 patients were enrolled, and 85 (4.83%) of the enrolled patients had HCV Ab seropositivity. Multivariable regression analyses revealed that albuminuria showed a dose-dependent association with HCV Ab seropositivity (UACR [30-299 mg/g]: odds ratio [OR] = 1.463, 95% confidence interval [CI] 0.872‒2.456); UACR [≥ 300 mg/g]: OR = 2.300, 95% CI 1.160‒4.562; P for trend = 0.015) when compared with normal albuminuria (UACR < 30 mg/g). However, the proportion of patients with peripheral arterial disease, defined as an ABI ≤ 0.9, was not significantly different between the groups with and without HCV Ab seropositivity (3.5% vs. 3.9%, P = 0.999). In conclusion, severely increased albuminuria, but not the ABI, showed a significant association with HCV Ab seropositivity in patients aged ≥ 50 years with type 2 DM.
丙型肝炎病毒（HCV）感染在 2 型糖尿病（DM）患者中较为普遍。本研究旨在探讨 HCV 抗体（Ab）阳性是否与糖尿病的微血管和大血管疾病有关。在这项基于医院的横断面研究中，我们回顾性地收集了 2021 年 1 月至 2022 年 3 月期间参加糖尿病按绩效付费计划并在年度综合评估中接受 HCV Ab 筛查的患者的数据。我们检查了年龄≥50 岁的 2 型 DM 患者中 HCV Ab 阳性与点尿白蛋白与肌酐比值（UACR）和踝臂指数（ABI）之间的关系。共纳入 1758 例患者，其中 85 例（4.83%）患者 HCV Ab 阳性。多变量回归分析显示，白蛋白尿与 HCV Ab 阳性呈剂量依赖性相关（UACR [30-299mg/g]：比值比[OR] = 1.463，95%置信区间[CI] 0.872-2.456）；UACR [≥300mg/g]：OR = 2.300，95%CI 1.160-4.562；P 趋势= 0.015），与正常白蛋白尿（UACR <30mg/g）相比。然而，ABI≤0.9 的周围动脉疾病患者比例在 HCV Ab 阳性和阴性组之间无显著差异（3.5%比 3.9%，P=0.999）。综上所述，在年龄≥50 岁的 2 型 DM 患者中，严重的白蛋白尿，而不是 ABI，与 HCV Ab 阳性显著相关。
