Proteomics Unit, Department of Biochemistry, Institute of Chemistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Laboratory of Proteomics (LabProt), LADETEC, Institute of Chemistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Adv Exp Med Biol. 2024;1443:63-85. doi: 10.1007/978-3-031-50624-6_4.
Zika virus (ZIKV) infection can be transmitted vertically, leading to the development of congenital Zika syndrome (CZS) in infected fetuses. During the early stages of gestation, the fetuses face an elevated risk of developing CZS. However, it is important to note that late-stage infections can also result in adverse outcomes. The differences between CZS and non-CZS phenotypes remain poorly understood. In this review, we provide a summary of the molecular mechanisms underlying ZIKV infection and placental and blood-brain barriers trespassing. Also, we have included molecular alterations that elucidate the progression of CZS by proteomics and metabolomics studies. Lastly, this review comprises investigations into body fluid samples, which have aided to identify potential biomarkers associated with CZS.
寨卡病毒（ZIKV）感染可垂直传播，导致受感染胎儿发生先天性寨卡综合征（CZS）。在妊娠早期，胎儿面临发生 CZS 的风险增加。然而，值得注意的是，晚期感染也可能导致不良后果。CZS 和非 CZS 表型之间的差异仍知之甚少。在这篇综述中，我们总结了寨卡病毒感染和胎盘及血脑屏障穿透的分子机制。此外，我们还包括了通过蛋白质组学和代谢组学研究阐明 CZS 进展的分子改变。最后，本综述包括对体液样本的研究，这些研究有助于鉴定与 CZS 相关的潜在生物标志物。
