Chaudhary Anurag, Krishnarth Neha, Tripathi Prabash, Chaudhary Amrendra Kumar, Rejeeth Chandrababu, Sharma Alok
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, NH-58, Baghpat Road Crossing, Bypass Road, Meerut-250005, India.
Raj Kumar Goel Institute of Technology (College of Pharmacy), 5th KM Stone Delhi, Meerut Road, Near Raj Nagar Extension Road, Ghaziabad, U.P-201003, India.
Pharm Nanotechnol. 2024 Feb 21. doi: 10.2174/0122117385274576240209054652.
In response to the escalating issue of antibiotic-resistant bacteria adhering to and thriving on medical equipment, scientists are pioneering innovative "intelligent" materials and coatings. These advancements entail the targeted release of antimicrobial substances, specifically activated when bacteria are detected. The next section discusses three revolutionary substances: hydrogels, nanoparticles, and thin films. Furthermore, intelligent antibacterial materials are divided into 2 groups based on the triggering source: those that react to biological stimuli and those that react to non-biological ones, like temperature and electric cues associated with bacterial presence, such as pH shifts or bacterial enzyme discharge. Moreover, because of their simple construction technique, outstanding biocompatibility, and robust antibacterial characteristics derived from polyphenols and metal ions, metallic-polyphenolic nanoparticles (MPNs) have obtained substantial interest in tackling antimicrobial infections. This article presents an introduction to several MPN-centered biomaterials (like nanoparticles, coatings, capsules, and hydrogels) and highlights the latest advancements in research in its applications for addressing microbial threats in the field of biomedicine. Furthermore, the usage of smart materials is classified based on their application domains, encompassing medical implants, waste reduction, and nano-engineered systems.
针对附着在医疗设备上并在其上繁衍的抗生素耐药菌问题不断升级的情况，科学家们正在开创创新的“智能”材料和涂层。这些进展涉及抗菌物质的靶向释放，特别是在检测到细菌时被激活。下一节将讨论三种革命性物质：水凝胶、纳米颗粒和薄膜。此外，智能抗菌材料根据触发源分为两类：对生物刺激作出反应的材料和对非生物刺激作出反应的材料，如与细菌存在相关的温度和电信号，如pH值变化或细菌酶释放。此外，由于金属多酚纳米颗粒（MPN）的构建技术简单、生物相容性优异以及源自多酚和金属离子的强大抗菌特性，它们在应对抗菌感染方面引起了极大关注。本文介绍了几种以MPN为中心的生物材料（如纳米颗粒、涂层、胶囊和水凝胶），并重点介绍了其在生物医学领域应对微生物威胁应用研究的最新进展。此外，智能材料的使用根据其应用领域进行分类，包括医疗植入物、废物减少和纳米工程系统。
