Department of Histology and Embryology, School of Basic Medical Sciences, Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510515, P. R. China.
Regenerative Medicine and Tissue Repair Research Center, Huangpu Institute of Materials, Guangzhou, 510530, P. R. China.
Adv Sci (Weinh). 2022 Sep;9(27):e2202684. doi: 10.1002/advs.202202684. Epub 2022 Jul 25.
Due to the abuse of antibiotics and the emergence of multidrug resistant microorganisms, medical devices, and related biomaterials are at high risk of microbial infection during use, placing a heavy burden on patients and healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, and antibacterial properties by making use of the coordination between phenolic ligands and metal ions. Further, MPNs have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and excellent antimicrobial properties brought about by polyphenols and metal ions. In this review, different categories of biomaterials based on MPNs (nanoparticles, coatings, capsules, hydrogels) and their fabrication strategies are summarized, and recent research advances in their antimicrobial applications in biomedical fields (e.g., skin repair, bone regeneration, medical devices, etc.) are highlighted.
由于抗生素的滥用和多药耐药微生物的出现，医疗器械和相关生物材料在使用过程中存在很高的微生物感染风险，给患者和医疗系统带来了沉重的负担。金属-酚网络（MPNs）是近年来逐渐发展起来的一种新兴的有机-无机杂化网络系统，利用酚配体与金属离子的配位作用，表现出优异的抗炎、抗氧化和抗菌性能。此外，由于 MPNs 具有简便的合成工艺、优异的生物相容性以及多酚和金属离子带来的优异抗菌性能，因此在抗菌感染方面受到了广泛关注。在这篇综述中，总结了基于 MPNs 的不同类别生物材料（纳米粒子、涂层、胶囊、水凝胶）及其制备策略，并重点介绍了它们在生物医学领域（例如皮肤修复、骨再生、医疗器械等）的抗菌应用中的最新研究进展。
