Radio S J, Suvalsky S D, Hofschire P J, Fleming W H, Rogler W C, McManus B M
Arch Pathol Lab Med. 1985 Dec;109(12):1118-21.
A 16-year-old boy developed marked calcific stenosis of an Ionescu-Shiley valve that was implanted in the aortic position 42 months before his sudden death. Renal hemosiderosis caused by intravascular hemolysis was quantitated by atomic absorption spectrophotometry. The accelerated calcification of the bovine pericardial valve in our patient supports the view that, in general, xenografts should not be used in adolescents. Frequent follow-up evaluations are imperative in young patients who receive these valves to avoid the irrevocable progression of valvular stenosis and hemolytic anemia.
一名16岁男孩在突然死亡前42个月植入主动脉位置的Ionescu-Shiley瓣膜出现明显钙化狭窄。通过原子吸收分光光度法定量检测血管内溶血引起的肾含铁血黄素沉着症。我们患者中牛心包瓣膜的加速钙化支持这样一种观点，即一般而言，异种移植物不应在青少年中使用。对于接受这些瓣膜的年轻患者，必须进行频繁的随访评估，以避免瓣膜狭窄和溶血性贫血不可逆转的进展。
