Grignon D J, Kirk M E, Haines D S
Arch Pathol Lab Med. 1985 Dec;109(12):1124-6.
A 69-year-old woman underwent a hysterectomy and bilateral salpingo-oophorectomy for a 20-cm right ovarian tumor. Multiple peritoneal and lymph node biopsy specimens were obtained to determine the clinical stage. Despite the surgeon's concern of malignancy, pathologic examination demonstrated a benign mucinous cystadenoma. Periaortic and external iliac lymph nodes showed an unusual granulomatous reaction, with multinucleated giant cells surrounding cholesterol-like clefts. Analysis of cyst fluid from the ovarian tumor revealed high concentrations of protein and lipid; the lipid component was predominantly free cholesterol (0.61 mumole/mL) and phospholipid (0.225 mumole/mL). We speculate that fluid from the ovarian neoplasm drained into regional lymph nodes, causing this unusual granulomatous response.
一名69岁女性因右侧卵巢有一个20厘米的肿瘤而接受了子宫切除术和双侧输卵管卵巢切除术。获取了多个腹膜和淋巴结活检标本以确定临床分期。尽管外科医生担心是恶性肿瘤，但病理检查显示为良性黏液性囊腺瘤。腹主动脉旁和髂外淋巴结出现了异常的肉芽肿反应，多核巨细胞围绕着类似胆固醇的裂隙。对卵巢肿瘤囊液的分析显示蛋白质和脂质浓度很高；脂质成分主要是游离胆固醇（0.61微摩尔/毫升）和磷脂（0.225微摩尔/毫升）。我们推测卵巢肿瘤的液体引流到区域淋巴结，导致了这种异常的肉芽肿反应。
