Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Neurology, Zhongshan Hospital of Traditional Chinese Medicine, Guangdong, China.
Brain Behav. 2024 Feb;14(2):e3435. doi: 10.1002/brb3.3435.
With the increasing aging population, dementia has become a significant socioeconomic burden. However, the effects of albumin on delayed recall (DR) impairment remain unclear, and there are limited reports on sex and race differences in this relationship. This study aimed to investigate the association between albumin levels and DR impairment in older adults.
A total of 1507 normal cognitive function and 553 DR impairment from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 were included in this cross-sectional analysis. Participants aged 60 years and above were assessed using the Consortium to Establish a Registry for Alzheimer's Disease DR (CERAD-DR) test to evaluate cognitive function. Participants were categorized into DR impairment and normal cognitive function groups according to their CERAD-DR scores. Logistic regression analyses, generalized additive models, and fitted smoothing curves were utilized for data analysis.
After adjusting for potential confounders, a negative association was found between albumin levels and cognitive function (odds ratio [OR] = 0.60, 95% confidence interval [CI] 0.41-0.87). Subgroup analysis stratified by sex, race/ethnicity, and age revealed that the negative association remained significant in men (OR = 0.53, 95%CI 032-0.87), Blacks (OR = 0.35, 95%CI 0.17-0.74), and the age group of 60-70 years (OR = 0.48, 95%CI 0.28-0.81). However, no significant association was observed in women (OR = 0.72, 95%CI 0.41-1.28), whites (OR = 0.58, 95%CI 0.31-1.07), or Mexican Americans (OR = 1.11, 95%CI 0.35-3.46), as well as the age group of 71-80 years (OR = 0.62, 95%CI 0.37-1.03).
Our study suggests that elevated albumin levels are associated with a decreased incidence of cognitive function impairment, particularly in older men and Blacks. This finding indicates that maintaining high levels of albumin may be beneficial for cognitive function in older adults.
随着人口老龄化的加剧，痴呆症已成为一个重大的社会经济负担。然而，白蛋白对延迟回忆（DR）损害的影响尚不清楚，并且关于这种关系的性别和种族差异的报告也很有限。本研究旨在探讨白蛋白水平与老年人 DR 损害之间的关系。
本横断面分析共纳入 1507 名认知功能正常和 553 名 DR 损害的来自 2011-2014 年国家健康和营养检查调查（NHANES）的参与者。使用认知障碍协会建立的阿尔茨海默病 DR 登记处（CERAD-DR）测试评估参与者的认知功能，年龄在 60 岁及以上的参与者进行评估。根据 CERAD-DR 评分将参与者分为 DR 损害组和认知功能正常组。使用逻辑回归分析、广义加性模型和拟合平滑曲线进行数据分析。
在调整了潜在混杂因素后，白蛋白水平与认知功能呈负相关（比值比[OR] = 0.60，95%置信区间[CI] 0.41-0.87）。按性别、种族/族裔和年龄分层的亚组分析显示，这种负相关在男性（OR = 0.53，95%CI 032-0.87）、黑人（OR = 0.35，95%CI 0.17-0.74）和 60-70 岁年龄组（OR = 0.48，95%CI 0.28-0.81）中仍然显著。然而，在女性（OR = 0.72，95%CI 0.41-1.28）、白人（OR = 0.58，95%CI 0.31-1.07）或墨西哥裔美国人（OR = 1.11，95%CI 0.35-3.46）以及 71-80 岁年龄组（OR = 0.62，95%CI 0.37-1.03）中，没有观察到显著的相关性。
本研究表明，白蛋白水平升高与认知功能损害发生率降低有关，特别是在老年男性和黑人中。这一发现表明，保持高水平的白蛋白可能对老年人的认知功能有益。
