Mao Peizhong
The Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA ; The Departments of Physiology and Pharmacology, Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
J Neurodegener Dis. 2013;2013:319898. doi: 10.1155/2013/319898. Epub 2012 Aug 30.
Dementia is a complex disorder that mostly affects the elderly and represents a significant and growing public health burden in the world. Alzheimer's disease (AD)- associated dementia and dementia with Lewy bodies (DLB) are the most common forms of dementia, in which oxidative stress is significantly involved. Oxidative stress mechanisms may have clinical applications, that is, providing information for potential biomarkers. Thus brain-rich peptides with an antioxidant property, such as CART (cocaine- and amphetamine-regulated transcript), may be promising new markers. This paper summarizes the progress in research regarding oxidative stress in dementia with a focus on potential biomarkers in the cerebrospinal fluid (CSF) in the main forms of dementia. Other central and peripheral biomarkers, especially those considered oxidative stress related, are also discussed. This paper aims to provide information to improve current understanding of the pathogenesis and progression of dementia. It also offers insight into the differential diagnosis of AD and DLB.
痴呆症是一种复杂的疾病，主要影响老年人，是全球日益严重的重大公共卫生负担。阿尔茨海默病（AD）相关痴呆症和路易体痴呆症（DLB）是最常见的痴呆症形式，其中氧化应激起着重要作用。氧化应激机制可能具有临床应用价值，即可为潜在生物标志物提供信息。因此，具有抗氧化特性的富含大脑的肽，如可卡因和苯丙胺调节转录物（CART），可能是很有前景的新标志物。本文总结了痴呆症氧化应激方面的研究进展，重点关注主要痴呆症形式中脑脊液（CSF）中的潜在生物标志物。还讨论了其他中枢和外周生物标志物，特别是那些被认为与氧化应激相关的生物标志物。本文旨在提供信息，以增进目前对痴呆症发病机制和进展的理解。它还为AD和DLB的鉴别诊断提供了见解。
