Li Jia-Meng, Bai Ya-Zhi, Liu Quan-Ying, Zhang Shuang-Qing
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Beijing 100050, China.
Nutrients. 2024 Nov 30;16(23):4163. doi: 10.3390/nu16234163.
Dementia affects millions of aged people globally and mainly results from oxidative stress. Selenium shows beneficial effects on dementia however it remains elusive for the mediation effect of oxidative stress on the association between selenium and cognition. The present study firstly investigated the potential mediation role of oxidative stress on the relationship of selenium and cognition.
A total of 2154 adults aged 60 years and older from the National Health and Nutrition Examination Survey 2011-2014 were selected for the study. Weighted multivariate linear regression, weighted logistic regression, and mediation effect analysis were employed to investigate the association among selenium intake, cognition, and oxidative stress.
Selenium intake was positively associated with cognition, albumin, and vitamin D, negatively associated with uric acid, and exhibited no correlation with gamma glutamyl transpeptidase (GGT). Cognition was positively correlated with albumin and vitamin D, negatively related to GGT, and had no association with uric acid. Albumin and vitamin D significantly mediated the relationship between selenium intake and cognition, and the mediation proportion values of albumin and vitamin D were 3.85% and 8.02%, respectively.
For the first time, our findings demonstrated that higher selenium intake decreased cognitive impairment and oxidative stress levels. Moreover, the relationship between selenium intake and cognition was mediated by oxidative stress.
痴呆症影响着全球数百万老年人，主要由氧化应激引起。硒对痴呆症有有益作用，然而氧化应激在硒与认知之间关联中的中介作用仍不明确。本研究首次调查了氧化应激在硒与认知关系中的潜在中介作用。
从2011 - 2014年国家健康与营养检查调查中选取了2154名60岁及以上的成年人进行研究。采用加权多元线性回归、加权逻辑回归和中介效应分析来研究硒摄入量、认知和氧化应激之间的关联。
硒摄入量与认知、白蛋白和维生素D呈正相关，与尿酸呈负相关，与γ-谷氨酰转肽酶（GGT）无相关性。认知与白蛋白和维生素D呈正相关，与GGT呈负相关，与尿酸无关联。白蛋白和维生素D显著介导了硒摄入量与认知之间的关系，白蛋白和维生素D的中介比例值分别为3.85%和8.02%。
我们的研究结果首次表明，较高的硒摄入量可降低认知障碍和氧化应激水平。此外，硒摄入量与认知之间的关系由氧化应激介导。
