Veziris Christina R, Hyland Matthew T, Kable Julie A, Wozniak Jeffrey R, Coles Claire D, May Philip A, Kalberg Wendy O, Sowell Elizabeth R, Jones Kenneth L, Riley Edward P, Mattson Sarah N
San Diego State University.
Emory University.
Res Sq. 2024 Feb 12:rs.3.rs-3922436. doi: 10.21203/rs.3.rs-3922436/v1.
This study evaluated criteria for Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE). Kable et al. (2022) assessed the validity of this diagnosis in a sample with low exposure to alcohol. The current study expanded this assessment to a sample with a wider age range and heavier alcohol exposure. Data were collected from participants (5-17y) with prenatal alcohol exposure (PAE) and typically developing controls at six Collaborative Initiative on Fetal Alcohol Spectrum Disorders sites using neuropsychological assessment and caregiver reports. Impairment was tested at 1SD, 1.5SD, and 2SD below the normative average and a modification of the adaptive functioning requirement was tested. Testing impairment at 1SD resulted in the highest endorsement rates in both groups. Our findings replicated the study by Kable et al. and show that current criteria captured a high rate of those with PAE and that requiring fewer adaptive functioning criteria resulted in higher sensitivity to PAE.
本研究评估了产前酒精暴露相关神经行为障碍（ND-PAE）的标准。凯布尔等人（2022年）在酒精暴露量较低的样本中评估了该诊断的有效性。当前研究将这一评估扩展至年龄范围更广、酒精暴露量更高的样本。数据是从胎儿酒精谱系障碍协作倡议的六个地点的产前酒精暴露（PAE）参与者（5-17岁）以及发育正常的对照组中收集的，采用了神经心理学评估和照顾者报告。在低于常模平均值1个标准差、1.5个标准差和2个标准差的水平上测试损伤情况，并对适应性功能要求进行了修改测试。在1个标准差水平上测试损伤情况时，两组的认可率最高。我们的研究结果重复了凯布尔等人的研究，表明当前标准涵盖了高比例的PAE患者，并且要求较少的适应性功能标准会导致对PAE的敏感性更高。
