Burkart W, Dame W R, Holzgreve W, Schneider H P
Geburtshilfe Frauenheilkd. 1985 Nov;45(11):809-12. doi: 10.1055/s-2008-1036653.
We measured the concentrations of growth hormone and corticosteroids in the amniotic fluid of 50 pregnant diabetic women between the 33rd and 36th week of gestation. These values were compared with normal values obtained by amniocentesis in 275 healthy patients. In the amniotic fluid the concentration of growth hormone decreases during pregnancy. Between the 12th and 16th week we measured 50 ng/ml, whereas in the last four weeks we found 30 ng/ml. In the diabetic patient the amniotic fluid content of STH is lower; however, hyperinsulinaemia of the foetus does not further decrease the concentration of growth hormone. The corticosteroid concentration in the amniotic fluid increases from 10 ng/ml in the 4th month of pregnancy to 35 ng/ml at the end of pregnancy. In diabetic patients we found lower cortisol concentrations; the concentration decreased further in the case of major symptoms of diabetic foetopathy in the newborn. We believe that low corticoid concentration in the amniotic fluid of the diabetic mother may be responsible for the respiratory distress syndrome in the newborn.
我们测定了50名妊娠糖尿病妇女在妊娠第33至36周时羊水内生长激素和皮质类固醇的浓度。这些值与275名健康孕妇羊水穿刺获得的正常值进行了比较。羊水中生长激素的浓度在孕期会下降。在第12至16周时，我们测得浓度为50纳克/毫升，而在最后四周，我们发现浓度为30纳克/毫升。糖尿病患者羊水中生长激素的含量较低；然而，胎儿的高胰岛素血症并未进一步降低生长激素的浓度。羊水中皮质类固醇的浓度从妊娠第4个月时的10纳克/毫升增加到妊娠末期的35纳克/毫升。在糖尿病患者中，我们发现皮质醇浓度较低；在新生儿出现主要糖尿病胎儿病变症状时，浓度会进一步降低。我们认为，糖尿病母亲羊水中皮质激素浓度低可能是新生儿呼吸窘迫综合征的原因。
