Smith B T, Worthington D, Maloney A H
Obstet Gynecol. 1977 May;49(5):527-31.
Cortisol and cortisone have been measured in amniotic fluid samples obtained within 24 hours of deliver of 50 premature infants. When expressed as cortisol/cortisone ratios, the ratio tends to rise with advancing gestational age, although statistical significance is not attained. Both cortisol concentration and the cortisol/cortisone ratio are significantly lower in the amniotic fluid of infants who develop respiratory distress syndrome than in those with mature lung function (cortisol ratio: 19.2 +/- 10.3 ng/ml vs 26.1 +/- 9.4, P less than .02; cortisol/cortisone ratio: 1.2 +/- 0.6 vs 2.0 +/- 0.8, P less than .001). These findings also hold in the subgroup of infants less than 32 weeks' gestation but not in those infants at or beyond the 32nd week. The amniotic fluid cortisone concentration is significantly lower in infants born after spontaneous labor beginning with rupture of the membranes as opposed to after contractions or bleeding (13.2 +/- 3.6 ng/ml vs 16.3 +/- 6.1, P less than .05), although the cortisol concentrations and the cortisol/cortisone ratios are not significantly different.
在50例早产儿分娩后24小时内采集的羊水样本中检测了皮质醇和可的松。以皮质醇/可的松比值表示时，该比值往往随胎龄增加而升高，尽管未达到统计学显著性。发生呼吸窘迫综合征的婴儿羊水中的皮质醇浓度和皮质醇/可的松比值均显著低于肺功能成熟的婴儿（皮质醇比值：19.2±10.3 ng/ml对26.1±9.4，P＜0.02；皮质醇/可的松比值：1.2±0.6对2.0±0.8，P＜0.001）。这些发现也适用于胎龄小于32周的婴儿亚组，但不适用于32周及以上的婴儿。与宫缩或出血后出生的婴儿相比，胎膜早破开始自然分娩后出生的婴儿羊水中的可的松浓度显著降低（13.2±3.6 ng/ml对16.3±6.1，P＜0.05），尽管皮质醇浓度和皮质醇/可的松比值无显著差异。
