Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
School of Data Science, University of Science and Technology of China, Hefei, China.
Cell Rep. 2024 Mar 26;43(3):113817. doi: 10.1016/j.celrep.2024.113817. Epub 2024 Feb 26.
Amino acid formula (AAF) is increasingly consumed in infants with cow's milk protein allergy; however, the long-term influences on health are less described. In this study, we established a mouse model by subjecting neonatal mice to an amino acid diet (AAD) to mimic the feeding regimen of infants on AAF. Surprisingly, AAD-fed mice exhibited dysbiotic microbiota and increased neuronal activity in both the intestine and brain, as well as gastrointestinal peristalsis disorders and depressive-like behavior. Furthermore, fecal microbiota transplantation from AAD-fed mice or AAF-fed infants to recipient mice led to elevated neuronal activations and exacerbated depressive-like behaviors compared to that from normal chow-fed mice or cow's-milk-formula-fed infants, respectively. Our findings highlight the necessity to avoid the excessive use of AAF, which may influence the neuronal development and mental health of children.
氨基酸配方（AAF）在牛乳蛋白过敏的婴儿中越来越受欢迎；然而，其对健康的长期影响描述较少。在这项研究中，我们通过给新生小鼠喂食氨基酸饮食（AAD）来建立一个小鼠模型，以模拟 AAF 喂养婴儿的喂养方案。令人惊讶的是，AAD 喂养的小鼠表现出肠道微生物失调和肠道及大脑神经元活动增加，以及胃肠道蠕动障碍和类似抑郁的行为。此外，与正常饲料喂养的小鼠或牛乳配方喂养的婴儿相比，从 AAD 喂养的小鼠或 AAF 喂养的婴儿粪便微生物群移植到受体小鼠中，会导致神经元活动增加和类似抑郁的行为加重。我们的研究结果强调了避免过度使用 AAF 的必要性，因为它可能会影响儿童的神经元发育和心理健康。
