van der Kogel A J, Sissingh H A
Radiother Oncol. 1985 Nov;4(3):239-51. doi: 10.1016/s0167-8140(85)80089-x.
The effect of intrathecally or intravenously administered methotrexate (MTX) or cytosine arabinoside (ara-C) on the early and late delayed radiation response of the rat cervical spinal cord has been studied. A technique has been developed for intrathecal administration of drugs into the rat lumbar spinal canal. When given shortly before irradiation, intrathecal ara-C significantly reduces the isoeffect doses for the early delayed white matter necrosis syndrome by a factor of 1.2-1.3, while no effect is observed for the late delayed vascular syndrome. The effect disappears when ara-C is given intravenously or 24 h after irradiation. In addition, intrathecal ara-C seems to impair the capacity of long-term regeneration. Intrathecal administration of MTX is limited by severe acute neurotoxicity. At a maximally tolerated intrathecal MTX dose, no modification of the early or late radiation response of the spinal cord was observed. In contrast to ara-C, intravenous MTX seems to interact with the induction of the late delayed vascular damage in the rat cervical spinal cord, with a dose-modifying factor of 1.1-1.2.
已研究了鞘内或静脉注射甲氨蝶呤（MTX）或阿糖胞苷（ara - C）对大鼠颈段脊髓早期和晚期延迟放射反应的影响。已开发出一种将药物鞘内注射到大鼠腰段椎管的技术。在照射前不久给予时，鞘内注射ara - C可使早期延迟性白质坏死综合征的等效效应剂量显著降低1.2 - 1.3倍，而对晚期延迟性血管综合征未观察到影响。当静脉注射ara - C或在照射后24小时给予时，该效应消失。此外，鞘内注射ara - C似乎会损害长期再生能力。鞘内注射MTX受到严重急性神经毒性的限制。在最大耐受的鞘内MTX剂量下，未观察到脊髓早期或晚期放射反应的改变。与ara - C相反，静脉注射MTX似乎与大鼠颈段脊髓晚期延迟性血管损伤的诱导相互作用，剂量修正因子为1.1 - 1.2。
