Ang K K, van der Kogel A J, van der Schueren E
J Neurooncol. 1986;3(4):349-52. doi: 10.1007/BF00165585.
The effect of combined AZQ (aziridinylbenzoquinone) and ionizing radiation on the rat spinal cord has been investigated. The highest dose of AZQ (3 mg/kg) tolerated by rats weighing 250 g was injected intravenously 15 min before a single dose of radiation or the first of 2 fractional doses. The development of paralysis due to white-matter necrosis in rats of each dose group was scored and dose-response curves were constructed. It has been found that a combination of AZQ with radiation did not lead to a significant shift of the dose-response curve as compared to that of radiation alone. Thus, AZQ administered according to the schedule used in the present study did not seem to reduce the radiation tolerance of the central nervous system.
研究了联合使用氮丙啶基苯醌（AZQ）和电离辐射对大鼠脊髓的影响。对体重250克的大鼠，在单次辐射剂量或2次分次剂量中的首次剂量照射前15分钟，静脉注射大鼠所能耐受的最高剂量AZQ（3毫克/千克）。对每个剂量组大鼠因白质坏死导致的瘫痪发展情况进行评分，并绘制剂量反应曲线。结果发现，与单独辐射相比，AZQ与辐射联合使用并未导致剂量反应曲线发生显著偏移。因此，按照本研究中使用的方案给药的AZQ似乎并未降低中枢神经系统的辐射耐受性。
