University of Health Sciences, Antalya Training and Research Hospital, Otorhinolaryngology and Head and Neck Surgery Clinic, Turkey.
University of Health Sciences, Antalya Training and Research Hospital, Neurology Clinic, Turkey.
Sleep Med. 2024 Apr;116:27-31. doi: 10.1016/j.sleep.2024.02.021. Epub 2024 Feb 17.
Obstructive sleep apnea (OSA) is a disease that may cause many medical conditions. Neurocognitive disorders may be triggered by OSA. In recent studies, selectively decreased gray matter tissue was observed in patients with OSA. We aimed to determine if there was a substantial difference in patients with extreme OSA by comparing the microstructural changes in different gray matter sub-areas with healthy controls using diffusion-weighted imaging methods.
We studied 15 diagnosed severe OSA subjects before any treatment and 32 healthy control subjects. High resolution Magnetic Resonance Imaging (MRI) T1 and T2-weighted scans were visually examined to assess any major brain lesions.
There were no statistically significant differences of age and gender between the groups.The left and right globus pallidus, putamen and thalamus values did not differ significantly between OSA and control subjects. Right putamen values was negatively correlated with Apnea Hypopnea Index (AHI), supine AHI and non-REM AHI in OSA subjects, but no correlations appeared with left putamen values. The other gray matter parameters did not show any correlations with PSG parameters. AHI, Supine AHI, Non-Supine AHI, REM and NON-REM AHI values was not show any correlation with Right and Left Putamen volume sizes.
We made a morphological comparison of various gray matter areas of OSA patients and healthy volunteers in our study. We observed a significant decrease in right putamen gray matter volumes in patients with higher AHI values. Decreased cognitive functions are found in patients with OSA. In order to demonstrate this cognitive loss in patients with morphologically there is a need for further prospective studies with larger sample sizes.
阻塞性睡眠呼吸暂停（OSA）是一种可能导致多种疾病的疾病。神经认知障碍可能由 OSA 引发。在最近的研究中，观察到 OSA 患者的灰质组织选择性减少。我们旨在通过使用扩散加权成像方法比较 OSA 患者与健康对照组不同灰质亚区的微观结构变化，确定极重度 OSA 患者是否存在实质性差异。
我们研究了 15 名未经任何治疗的确诊重度 OSA 患者和 32 名健康对照者。高分辨率磁共振成像（MRI）T1 和 T2 加权扫描进行了目视检查，以评估是否存在任何主要脑病变。
两组在年龄和性别方面无统计学差异。OSA 和对照组的左、右苍白球、壳核和丘脑值无显著差异。右壳核值与 OSA 患者的呼吸暂停低通气指数（AHI）、仰卧位 AHI 和非 REM AHI 呈负相关，但与左壳核值无相关性。其他灰质参数与 PSG 参数均无相关性。AHI、仰卧位 AHI、非仰卧位 AHI、REM 和 NON-REM AHI 值与右和左壳核体积大小无相关性。
在本研究中，我们对 OSA 患者和健康志愿者的各种灰质区域进行了形态比较。我们观察到 AHI 值较高的患者右壳核灰质体积显著减少。OSA 患者存在认知功能下降。为了在形态学上证明这种认知丧失，需要进一步进行前瞻性研究，样本量更大。
