Wang Yali, Wang Donglei, Hao Hongyu, Cui Jinjin, Huang Lihua, Liang Qingqing
School of Public Health, Baotou Medical College, Baotou 014030, Inner Mongolia, China.
School of Public Health, Baotou Medical College, Baotou 014030, Inner Mongolia, China.
J Hazard Mater. 2024 May 5;469:133828. doi: 10.1016/j.jhazmat.2024.133828. Epub 2024 Feb 20.
According to the World Health Organization, chronic obstructive pulmonary disease (COPD) was one of the top ten causes of death worldwide in 2019. The ratio of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC) provides a useful indicator for the diagnosis of COPD. Existing data have demonstrated that cadmium (Cd) exposure is associated with COPD. However, data concerning the incidence and progression of cadmium-induced COPD is inconsistent. To explore the relationship between cadmium exposure and the risk of COPD in humans, through January 12, 2023, we conducted a thorough search of the PubMed, Cochrane, Web of Science, Embase and Scopus databases for relevant material. In this study, a meta-analysis was conducted to evaluate the association between cadmium and COPD. This meta-analysis indicated that exposure to cadmium (per 1 μg/L increase) was associated with reduced FEV1/FVC (% change = -47.54%, 95% CI: -54.99% to -40.09%). Subgroup analysis showed that the combined effect estimates were significantly higher in the COPD patient group (% change = -54.66%, 95% CI: -83.32% to -26.00%) than in the general population (% change = -52.11%, 95%CI: -60.53% to -43.70%). Therefore, we conclude that cadmium exposure is associated with reduced FEV1/FVC, which suggests a risk for COPD.
根据世界卫生组织的数据，慢性阻塞性肺疾病（COPD）是2019年全球十大死因之一。第一秒用力呼气量与用力肺活量的比值（FEV1/FVC）为COPD的诊断提供了一个有用的指标。现有数据表明，镉（Cd）暴露与COPD有关。然而，关于镉诱导的COPD的发病率和进展的数据并不一致。为了探讨镉暴露与人类COPD风险之间的关系，截至2023年1月12日，我们对PubMed、Cochrane、科学网、Embase和Scopus数据库进行了全面搜索以获取相关资料。在本研究中，进行了一项荟萃分析以评估镉与COPD之间的关联。该荟萃分析表明，镉暴露（每增加1μg/L）与FEV1/FVC降低有关（变化百分比=-47.54%，95%CI：-54.99%至-40.09%）。亚组分析显示，COPD患者组的合并效应估计值（变化百分比=-54.66%，95%CI：-83.32%至-26.00%）显著高于一般人群（变化百分比=-52.11%，95%CI：-60.53%至-43.70%）。因此，我们得出结论，镉暴露与FEV1/FVC降低有关，这表明存在患COPD的风险。
