Aumaitre O, Pouplard-Barthelaix A, Thieblot P, Dordain G, Moinade S
Ann Med Interne (Paris). 1985;136(6):470-3.
The authors observed one case of myoclonic dementia reversible with steroid therapy, associated with Grave's disease and Sjögren's syndrome. A circulating IgG fraction was demonstrated reacting specifically with cerebral micro-vessels and which evolved in parallel with the neuro-psychiatric disturbances. These results support the hypothesis of an autoimmune vasculitis causing the dementia. The persistence of abnormalities one year after clinical cure showing an alteration of the blood-brain barrier associated with the appearance of circulating antibodies against the hypophyseal cells, and in view of the predictive value of these antibodies, suggests a possibility of the eventual apparition of an Alzheimer type dementia.
作者观察到1例肌阵挛性痴呆患者，其病情经类固醇治疗后可逆，该患者同时患有格雷夫斯病和干燥综合征。研究证实，一种循环IgG组分可与脑微血管发生特异性反应，且其变化与神经精神障碍平行。这些结果支持自身免疫性血管炎导致痴呆的假说。临床治愈一年后异常情况依然存在，表现为血脑屏障改变，并出现针对垂体细胞的循环抗体，鉴于这些抗体的预测价值，提示最终可能会出现阿尔茨海默病型痴呆。
