Allergy Department, Complejo Hospitalario Universitario de Santiago, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.
Pneumology Department, Hospital Vall d'Hebron, Barcelona, Spain.
Int Arch Allergy Immunol. 2024;185(5):456-459. doi: 10.1159/000536488. Epub 2024 Feb 27.
Changes in the cytokine profile from type 2 to type 1 together with the induction of regulatory cells are expected during hymenoptera venom immunotherapy (VIT). The present study was aimed to investigate the changes in type 1, type 2, and regulatory cytokines induced by a Vespula spp. VIT in patients with anaphylaxis to Vespa velutina.
Twenty consecutive patients with anaphylaxis due to Vespa velutina were treated with Vespula spp. VIT. Serum cytokines (IL-4, IL-5, IL-10, IL-13, and IFN-ɣ) were measured at baseline, 6, and 12 months after starting VIT.
A significant increase in serum IFN-y was detected after 6 and 12 months of VIT. An increase in serum IL-10 and a decrease in IL-5 were observed after 12 months. IL-4 was undetectable all along the study, and an unexpected increase of IL-13 was present at 12 months of treatment.
Vespula spp. VIT seems to be able to induce a shift to type 1 cytokine production measured through IFN-y levels and IL-10 production after, at least, 6 and 12 months of VIT, respectively.
在膜翅目毒液免疫疗法（VIT）期间，预计细胞因子谱会从 2 型向 1 型转变，同时诱导调节性细胞。本研究旨在调查由 Vespula spp. VIT 引起的 1 型、2 型和调节性细胞因子在对 Vespa velutina 过敏的患者中的变化。
20 例因 Vespa velutina 而出现过敏反应的患者接受了 Vespula spp. VIT 治疗。在开始 VIT 治疗后的 6 个月和 12 个月时测量血清细胞因子（IL-4、IL-5、IL-10、IL-13 和 IFN-ɣ）。
在 VIT 治疗 6 个月和 12 个月后，血清 IFN-γ水平显著增加。在 12 个月时观察到血清 IL-10 增加和 IL-5 减少。整个研究过程中均未检测到 IL-4，而在治疗 12 个月时意外出现了 IL-13 的增加。
Vespula spp. VIT 似乎能够诱导细胞因子产生向 1 型转变，通过 IFN-γ水平和至少 6 个月和 12 个月 VIT 后的 IL-10 产生来测量。
