National Research and Development Centre for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, P. R. China.
Institute for Agro-Industries, Industrial Research and Consultancy Centre (IRCC), Khartoum, 400076, Sudan.
Macromol Biosci. 2024 Jun;24(6):e2300520. doi: 10.1002/mabi.202300520. Epub 2024 Mar 8.
Hydrogels have emerged as a promising option for treating local scald wounds due to their unique physical and chemical properties. This study aims to evaluate the efficacy of ovalbumin/gelatin composite hydrogels in repairing deep II-degree scald wounds using a mouse dorsal skin model. Trauma tissues collected at various time points are analyzed for total protein content, hydroxyproline content, histological features, and expression of relevant markers. The results reveal that the hydrogel accelerates the healing process of scalded wounds, which is 17.27% higher than the control group. The hydrogel treatment also effectively prevents wound enlargement and redness of the edges caused by infection during the initial stage of scalding. The total protein and hydroxyproline content of the treated wounds are significantly elevated. Additionally, the hydrogel up-regulates the expression of VEGF (a crucial angiogenic factor) and down-regulates CD68 (a macrophage marker). In summary, this study provides valuable insights into the potential of multifunctional protein-based hydrogels in wound healing.
水凝胶因其独特的物理和化学性质，已成为治疗局部烫伤创面的一种有前途的选择。本研究旨在通过小鼠背部皮肤模型评估卵清白蛋白/明胶复合水凝胶在修复深二度烫伤创面中的疗效。分析不同时间点采集的创伤组织的总蛋白含量、羟脯氨酸含量、组织学特征和相关标志物的表达。结果表明，水凝胶加速了烫伤创面的愈合过程，比对照组高 17.27%。水凝胶处理还可以有效防止烫伤初期感染引起的创面扩大和边缘红肿。治疗后的创面总蛋白和羟脯氨酸含量明显升高。此外，水凝胶上调了 VEGF（一种关键的血管生成因子）的表达，下调了 CD68（一种巨噬细胞标志物）的表达。综上所述，本研究为多功能蛋白基水凝胶在伤口愈合中的潜在应用提供了有价值的见解。
