Coruzzi G, Poli E, Bertaccini G
Gen Pharmacol. 1985;16(6):561-6. doi: 10.1016/0306-3623(85)90143-0.
Several compounds acting on the cholinergic system at different levels were tested for their stimulatory or inhibitory effects on the isolated lower esophageal sphincter (LES) of the rat. Results obtained with acetylcholine, bethanechol and compound McN-A343 on the one hand and atropine, pirenzepine, ganglion blocking agents and tetrodotoxin on the other, suggested that LES contraction was associated mainly with the stimulation of post-synaptic muscarinic receptors. Nicotinic receptors (both ganglionic and muscular) seem to have a minor role, if any.
测试了几种在不同水平作用于胆碱能系统的化合物对大鼠离体下食管括约肌（LES）的刺激或抑制作用。一方面，乙酰胆碱、氨甲酰甲胆碱和化合物McN-A343的实验结果，另一方面，阿托品、哌仑西平、神经节阻断剂和河豚毒素的实验结果表明，LES收缩主要与突触后毒蕈碱受体的刺激有关。烟碱受体（神经节和肌肉型）即便有作用，似乎也很微小。
