School of Public Health, Shenyang Medical College, Shenyang, 110034, China.
Officers' Ward Department, General Hospital of Northern Theater Command, Shenyang, 110034, China.
Nutr Metab Cardiovasc Dis. 2024 Apr;34(4):1008-1013. doi: 10.1016/j.numecd.2023.12.023. Epub 2023 Dec 30.
Uric acid, the end-product of purine metabolism within the human body, has been the subject of studies exploring its potential association with cardiovascular and cerebrovascular diseases. However, the precise relationship between uric acid levels and heart failure remains elusive.
In this particular study, aggregated data from genome-wide association studies on uric acid and heart failure were utilized to perform a two-sample Mendelian randomization (MR) analysis utilizing R software. The aim was to uncover any causal link between these variables. The primary outcome was assessed using inverse variance weighted (IVW) methodology, while sensitivity analyses employed MR-Egger, weighted median (WME), and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) techniques. IVW results revealed a possible causal relationship between elevated uric acid levels and an increased risk of heart failure (OR: 1.09, 95 % CI: 1.01-1.17, P < 0.05). Encouragingly, the directions provided by MR-Egger and WME aligned with IVW findings, and no anomalies were detected in the remaining sensitivity analyses.
These outcomes indicate the stability of the results of the study, thereby suggesting that heightened uric acid levels may contribute to an augmented risk of heart failure.
尿酸是人体嘌呤代谢的终产物，已有研究探讨其与心脑血管疾病的潜在关联。然而，尿酸水平与心力衰竭之间的确切关系仍不清楚。
本研究利用尿酸和心力衰竭的全基因组关联研究汇总数据，使用 R 软件进行两样本 Mendelian 随机化（MR）分析，以揭示这些变量之间的因果关系。主要结局采用逆方差加权（IVW）方法评估，敏感性分析采用 MR-Egger、加权中位数（WME）和 MR 偏倚剩余和异常值（MR-PRESSO）技术。IVW 结果表明，尿酸水平升高与心力衰竭风险增加之间可能存在因果关系（OR：1.09，95%CI：1.01-1.17，P<0.05）。令人鼓舞的是，MR-Egger 和 WME 的结果与 IVW 一致，其余敏感性分析中未发现异常。
这些结果表明研究结果稳定，提示尿酸水平升高可能导致心力衰竭风险增加。
