State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Signal Transduct Target Ther. 2024 Feb 28;9(1):38. doi: 10.1038/s41392-024-01755-x.
Metabolic diseases and their complications impose health and economic burdens worldwide. Evidence from past experimental studies and clinical trials suggests our body may have the ability to remember the past metabolic environment, such as hyperglycemia or hyperlipidemia, thus leading to chronic inflammatory disorders and other diseases even after the elimination of these metabolic environments. The long-term effects of that aberrant metabolism on the body have been summarized as metabolic memory and are found to assume a crucial role in states of health and disease. Multiple molecular mechanisms collectively participate in metabolic memory management, resulting in different cellular alterations as well as tissue and organ dysfunctions, culminating in disease progression and even affecting offspring. The elucidation and expansion of the concept of metabolic memory provides more comprehensive insight into pathogenic mechanisms underlying metabolic diseases and complications and promises to be a new target in disease detection and management. Here, we retrace the history of relevant research on metabolic memory and summarize its salient characteristics. We provide a detailed discussion of the mechanisms by which metabolic memory may be involved in disease development at molecular, cellular, and organ levels, with emphasis on the impact of epigenetic modulations. Finally, we present some of the pivotal findings arguing in favor of targeting metabolic memory to develop therapeutic strategies for metabolic diseases and provide the latest reflections on the consequences of metabolic memory as well as their implications for human health and diseases.
代谢性疾病及其并发症在全球范围内给健康和经济带来了负担。过去的实验研究和临床试验证据表明，我们的身体可能有能力记住过去的代谢环境，如高血糖或高血脂，即使在消除这些代谢环境后，也会导致慢性炎症紊乱和其他疾病。这种异常代谢对身体的长期影响被总结为代谢记忆，并被发现在健康和疾病状态中起着至关重要的作用。多种分子机制共同参与代谢记忆的管理，导致不同的细胞改变以及组织和器官功能障碍，最终导致疾病进展，甚至影响后代。代谢记忆概念的阐明和扩展为代谢性疾病和并发症的发病机制提供了更全面的认识，并有望成为疾病检测和管理的新靶点。在这里，我们追溯了代谢记忆相关研究的历史，并总结了其显著特征。我们详细讨论了代谢记忆可能在分子、细胞和器官水平上参与疾病发展的机制，重点强调了表观遗传调控的影响。最后，我们提出了一些支持针对代谢记忆开发代谢性疾病治疗策略的关键发现，并对代谢记忆的后果及其对人类健康和疾病的影响进行了最新的思考。
