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糖尿病及相关血管疾病:发病机制、并发症与不断发展的治疗方法

Diabetes Mellitus and Associated Vascular Disease: Pathogenesis, Complications, and Evolving Treatments.

作者信息

Islam Kazi, Islam Rahib, Nguyen Ivan, Malik Hassan, Pirzadah Humza, Shrestha Barsha, Lentz Isabella B, Shekoohi Sahar, Kaye Alan D

机构信息

Central State University, 1400 Brush Row Road, Wilberforce, OH, 45384, USA.

LSU Health Sciences Center New Orleans School of Medicine, 1901 Gravier Street, New Orleans, LA, 70112, USA.

出版信息

Adv Ther. 2025 Jun;42(6):2659-2678. doi: 10.1007/s12325-025-03185-9. Epub 2025 Apr 19.


DOI:10.1007/s12325-025-03185-9
PMID:40252164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12085338/
Abstract

Diabetes mellitus is a metabolic disorder, characterized by elevated blood sugar levels (hyperglycemia) and insulin dysregulation. This disease is associated with morbidity and mortality, including significant potential vascular complications. High levels of hyperglycemia lead to not only elevated levels of reactive oxygen species but also advanced glycation end products, which are detrimental to the vascular endothelium and reduce protective compounds such as nitric oxide and prostacyclin. This damage contributes to the development of both macrovascular and microvascular complications. The present investigation explores the pathophysiological mechanisms of diabetic vascular complications and evaluates current management strategies, including lifestyle modifications, pharmacological treatments, and emerging therapies. The review underscores the importance of ongoing progress in diabetes management and patient education to lead to optimal patient-health outcomes and quality of life for individuals with diabetes mellitus.

摘要

糖尿病是一种代谢紊乱疾病,其特征为血糖水平升高(高血糖症)和胰岛素调节异常。这种疾病与发病率和死亡率相关,包括严重的潜在血管并发症。高水平的高血糖不仅会导致活性氧物质水平升高,还会产生晚期糖基化终末产物,这些物质对血管内皮有害,并会减少一氧化氮和前列环素等保护性化合物。这种损伤会促使大血管和微血管并发症的发生。本研究探讨了糖尿病血管并发症的病理生理机制,并评估了当前的管理策略,包括生活方式改变、药物治疗和新兴疗法。该综述强调了在糖尿病管理和患者教育方面不断取得进展对于实现糖尿病患者最佳健康结局和生活质量的重要性。

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Diabetes Mellitus and Associated Vascular Disease: Pathogenesis, Complications, and Evolving Treatments.

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[2]
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[3]
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本文引用的文献

[1]
The importance of exercise for glycemic control in type 2 diabetes.

Am J Med Open. 2023-1-18

[2]
Expert opinion on screening, diagnosis and management of diabetic peripheral neuropathy: a multidisciplinary approach.

Front Endocrinol (Lausanne). 2024

[3]
Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications.

Front Endocrinol (Lausanne). 2024-4-5

[4]
Mediterranean diet for cardiovascular disease: an evidence mapping study.

Public Health Nutr. 2024-4-11

[5]
Metabolic memory: mechanisms and diseases.

Signal Transduct Target Ther. 2024-2-28

[6]
Anti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications.

Ther Adv Endocrinol Metab. 2024-1-27

[7]
The benefits of GLP1 receptors in cardiovascular diseases.

Front Clin Diabetes Healthc. 2023-12-8

[8]
A Comprehensive Review of the Vascular Consequences of Diabetes in the Lower Extremities: Current Approaches to Management and Evaluation of Clinical Outcomes.

Cureus. 2023-10-23

[9]
Economic Costs of Diabetes in the U.S. in 2022.

Diabetes Care. 2024-1-1

[10]
Exploring the Cardiovascular Benefits of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors: Expanding Horizons Beyond Diabetes Management.

Cureus. 2023-9-30

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