Department of Biotechnology, BITS Pilani, Dubai Campus, Academic City, Dubai, UAE.
Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Dubai, UAE; New York University-Abu Dhabi, Abu Dhabi, UAE.
Drug Discov Today. 2023 Sep;28(9):103684. doi: 10.1016/j.drudis.2023.103684. Epub 2023 Jun 27.
Hurdles in the identification of new drugs for cancer treatment have made drug repurposing an increasingly appealing alternative. The approach involves the use of old drugs for new therapeutic purposes. It is cost-effective and facilitates rapid clinical translation. Given that cancer is also considered a metabolic disease, drugs for metabolic disorders are being actively repurposed for cancer therapeutics. In this review, we discuss the repurposing of such drugs approved for two major metabolic diseases, diabetes and cardiovascular disease (CVD), which have shown potential as anti-cancer treatment. We also highlight the current understanding of the cancer signaling pathways that these drugs target.
癌症治疗新药的研发遇到了重重困难，使得药物重用以成为一种越来越有吸引力的替代方案。这种方法是将旧药用于新的治疗目的。它具有成本效益，并且便于快速临床转化。鉴于癌症也被认为是一种代谢疾病，用于治疗代谢紊乱的药物也正在被积极地重新用于癌症治疗。在这篇综述中，我们讨论了两种主要代谢疾病（糖尿病和心血管疾病）的已批准药物的重新应用，这些药物在癌症治疗中显示出了潜力。我们还强调了目前对这些药物靶向的癌症信号通路的理解。
